ArticleHuman genetics2009
Genome-wide association scan for stature in Chinese: evidence for ethnic specific loci.
Article in Human genetics, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 4 of them syntheses that pooled it.
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Who cites it
24 citing papers in PubMed, 4 syntheses or guidelines pooled it.
- Meta-analysis of genome-wide association studies of adult height in East Asians identifies 17 novel loci.Human molecular genetics · 2015Pooled it
- On individual genome-wide association studies and their meta-analysis.Human genetics · 2014Pooled it
- Genome-wide association study in Han Chinese identifies three novel loci for human height.Human genetics · 2013Pooled it
- Genome-wide association study of body height in African Americans: the Women's Health Initiative SNP Health Association Resource (SHARe).Human molecular genetics · 2012Pooled it
- Genome-wide association study of patient-rated and clinician-rated global impression of severity during antipsychotic treatment.Pharmacogenetics and genomics · 2013Trial
- Pharmacogenomic study of side-effects for antidepressant treatment options in STAR*D.Psychological medicine · 2012Trial
- Advancing drug discovery using the power of the human genome.The Journal of pathology · 2021Review
- Complex Phenotypes: Mechanisms Underlying Variation in Human Stature.Current osteoporosis reports · 2019Review
- Population-specific genetic modification of Huntington's disease in Venezuela.PLoS genetics · 2018Article
- Northern Chinese dental ages estimated from southern Chinese reference datasets closely correlate with chronological age.Heliyon · 2016Article
- Whole-exome imputation of sequence variants identified two novel alleles associated with adult body height in African Americans.Human molecular genetics · 2014Article
- Genetic diversities of cytochrome B in Xinjiang Uyghur unveiled its origin and migration history.BMC genetics · 2013Article
- Confounding and heterogeneity in genetic association studies with admixed populations.American journal of epidemiology · 2013Article
- Genome-wide pharmacogenomic study of citalopram-induced side effects in STAR*D.Translational psychiatry · 2012Article
- Autosomal linkage scan for loci predisposing to comorbid dependence on multiple substances.American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics · 2012Article
- The use of race, ethnicity and ancestry in human genetic research.The HUGO journal · 2011Article
- Genome-wide pharmacogenomic study of neurocognition as an indicator of antipsychotic treatment response in schizophrenia.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2011Article
- Genome-wide association study SNPs in the human genome diversity project populations: does selection affect unlinked SNPs with shared trait associations?PLoS genetics · 2011Article
- Polymorphisms in predicted miRNA binding sites and osteoporosis.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2011Article
- Runs of homozygosity identify a recessive locus 12q21.31 for human adult height.The Journal of clinical endocrinology and metabolism · 2010Article
Corrections and comments
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Authors and funding
19 authors.
Funding
Abstract
In Caucasian, several studies have identified some common variants associated with human stature variation. However, no such study was performed in Chinese, which is the largest population in the world and evidently differs from Caucasian in genetic background. To identify common or ethnic specific genes for stature in Chinese, an initial GWAS and follow-up replication study were performed. Our initial GWAS study found that a group of 13 contiguous SNPs, which span a region of approximately 150 kb containing two neighboring genes, zinc finger protein (ZNP) 510 and ZNP782, achieved strong signals for association with stature, with P values ranging from 9.71 x 10(-5) to 3.11 x 10(-6). After false discovery rate correction for multiple testing, 9 of the 13 SNPs remain significant (FDR q=0.036-0.046). The follow-up replication study in an independent 2,953 unrelated southern Chinese confirmed the association of rs10816533 with stature (P=0.029). All the 13 SNPs were in consistently strong linkage disequilibrium (D'>0.99) and formed a single perfect haplotype block. The minor allele frequencies for the 13 contiguous SNPs have evidently ethnic difference, which range from 0.21 to 0.33 in Chinese but have as low as approximately 0.017 reported in dbSNP database in Caucasian. The present results suggest that the genomic region containing the ZNP510 and ZNP782 genes is an ethnic specific locus associated with stature variation in Chinese.
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