ArticleEuropean journal of applied physiology2009
Dissociation between force and maximal Na+, K +-ATPase activity in rat fast-twitch skeletal muscle with fatiguing in vitro stimulation.
Article in European journal of applied physiology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
4 citing papers in PubMed, 5 citations in OpenAlex.
- Fatiguing high-intensity intermittent exercise depresses maximal NaPflugers Archiv : European journal of physiology · 2025Article
- A century of exercise physiology: effects of muscle contraction and exercise on skeletal muscle NaEuropean journal of applied physiology · 2024Review
- Cisplatin-Induced Skeletal Muscle Dysfunction: Mechanisms and Counteracting Therapeutic Strategies.International journal of molecular sciences · 2020Review
- Quantification of Na+,K+ pumps and their transport rate in skeletal muscle: functional significance.The Journal of general physiology · 2013Review
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
This study investigated whether high frequency in vitro stimulation of rat fast-twitch extensor digitorum longus muscle depresses Na(+), K(+)-ATPase (NKA) activity as measured by the maximal in vitro 3-O-MFPase assay. EDL muscles subjected to 10 s continuous 100 Hz stimulation reduced tetanic force by 51.8 +/- 5.1% which recovered to 81.2 +/- 6.1% after 1 min and remained stable over 1 h recovery period. A second bout reduced force by 50.3 +/- 3.8% of initial but had no effect on 3-O-MFPase activity. Three minutes of intermittent stimulation (1 s at 100 Hz and 4 s recovery) resulted in 87.0 +/- 2.8% decline force with slow recovery (62.7 +/- 5.8% of initial after 1 h). The second 3-min bout reduced force by 83.3 +/- 3.6% of initial with no change in maximal 3-O-MFPase activity. These findings contrast previous human studies where fatiguing voluntary exercise depresses maximal NKA activity. This suggests that NKA in rat fast-twitch muscle is resistant to fatigue-induced inactivation under these conditions. Furthermore, the loss of force with fatigue was not related to depressed maximal NKA activity.
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