ArticleWorld journal of gastroenterology2008
Adiponectin deficiency enhances colorectal carcinogenesis and liver tumor formation induced by azoxymethane in mice.
Article in World journal of gastroenterology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 2 of them syntheses that pooled it.
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Who cites it
16 citing papers in PubMed, 2 syntheses or guidelines pooled it, 38 citations in OpenAlex.
- Serum adiponectin levels may be associated with the pathogenesis of hepatocellular carcinoma.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2015Pooled it
- Associations between variants on ADIPOQ and ADIPOR1 with colorectal cancer risk: a Chinese case-control study and updated meta-analysis.BMC medical genetics · 2014Pooled it
- The Oncogenic Burden of Obesity: Mechanistic Links Between Adiposity and Gastrointestinal Cancers-A Comprehensive Narrative Review.Biomedicines · 2025Review
- The Adipose Tissue at the Crosstalk Between EDCs and Cancer Development.Frontiers in endocrinology · 2021Review
- Targeting mTOR and Src restricts hepatocellular carcinoma growth in a novel murine liver cancer model.PloS one · 2019Article
- The fat and the bad: Mature adipocytes, key actors in tumor progression and resistance.Oncotarget · 2017Review
- Obesity promotes colonic stem cell expansion during cancer initiation.Cancer letters · 2015Article
- Tumor-promoting/progressing role of additional chromosome instability in hepatic carcinogenesis in Sgo1 (Shugoshin 1) haploinsufficient mice.Carcinogenesis · 2015Article
- Serum adiponectin and resistin levels in de novo and relapsed acute lymphoblastic leukemia children patients.Iranian journal of public health · 2013Article
- Role of adiponectin and its receptors in cancer.Cancer biology & medicine · 2012Article
- Obesity, energy balance, and cancer: new opportunities for prevention.Cancer prevention research (Philadelphia, Pa.) · 2012Review
- The role of adiponectin in cancer: a review of current evidence.Endocrine reviews · 2012Review
- Adiponectin deficiency: role in chronic inflammation induced colon cancer.Biochimica et biophysica acta · 2012Article
- Adiponectin deficiency promotes tumor growth in mice by reducing macrophage infiltration.PloS one · 2010Article
- Adiponectin represses colon cancer cell proliferation via AdipoR1- and -R2-mediated AMPK activation.Molecular endocrinology (Baltimore, Md.) · 2010Article
- Adiponectin action from head to toe.Endocrine · 2010Review
Corrections and comments
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Authors and funding
13 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimTo investigate the causal relationship between hypoadiponectinemia and colorectal carcinogenesis in in vivo experimental model, and to determine the contribution of adiponectin deficiency to colorectal cancer development and proliferation.
methodsWe examined the influence of adiponectin deficiency on colorectal carcinogenesis induced by the administration of azoxymethane (AOM) (7.5 mg/kg, intraperitoneal injection once a week for 8 wk), by using adiponectin-knockout (KO) mice.
resultsAt 53 wk after the first AOM treatment, KO mice developed larger and histologically more progressive colorectal tumors with greater frequency compared with wild-type (WT) mice, although the tumor incidence was not different between WT and KO mice. KO mice showed increased cell proliferation of colorectal tumor cells, which correlated with the expression levels of cyclooxygenase-2 (COX-2) in the colorectal tumors. In addition, KO mice showed higher incidence and frequency of liver tumors after AOM treatment. Thirteen percent of WT mice developed liver tumors, and these WT mice had only a single tumor. In contrast, 50% of KO mice developed liver tumors, and 58% of these KO mice had multiple tumors.
conclusionAdiponectin deficiency enhances colorectal carcinogenesis and liver tumor formation induced by AOM in mice. This study strongly suggests that hypoadiponectinemia could be involved in the pathogenesis for colorectal cancer and liver tumor in human subjects.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.