ArticlePloS one2008
Mosaic DNA imports with interspersions of recipient sequence after natural transformation of Helicobacter pylori.
Article in PloS one, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
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Who cites it
31 citing papers in PubMed, 37 citations in OpenAlex.
- Article
- Within-host diversity and phased variant analysis reveal structures and recombination of Helicobacter pylori subpopulations in stomach.GigaScience · 2026Article
- RecombinantAntibiotics (Basel, Switzerland) · 2022Review
- Article
- The acquisition of clinically relevant amoxicillin resistance in Streptococcus pneumoniae requires ordered horizontal gene transfer of four loci.PLoS pathogens · 2022Article
- Experimental Evolution ofGenetics · 2020Article
- Excision and transfer of an integrating and conjugative element in a bacterial species with high recombination efficiency.Scientific reports · 2019Article
- Recombination-independent rapid convergent evolution of the gastric pathogen Helicobacter pylori.BMC genomics · 2018Article
- Blending genomes: distributive conjugal transfer in mycobacteria, a sexier form of HGT.Molecular microbiology · 2018Review
- Genome-wide analysis of chromosomal import patterns after natural transformation of Helicobacter pylori.Nature communications · 2016Article
- Article
- Decoding cyanobacterial phylogeny and molecular evolution using an evonumeric approach.Protoplasma · 2015Article
- The complex methylome of the human gastric pathogen Helicobacter pylori.Nucleic acids research · 2014Article
- Description of an unusual Neisseria meningitidis isolate containing and expressing Neisseria gonorrhoeae-Specific 16S rRNA gene sequences.Journal of clinical microbiology · 2013Article
- Genomic evolution and transmission of Helicobacter pylori in two South African families.Proceedings of the National Academy of Sciences of the United States of America · 2013Article
- Distributive conjugal transfer in mycobacteria generates progeny with meiotic-like genome-wide mosaicism, allowing mapping of a mating identity locus.PLoS biology · 2013Article
- Genome sequence of Helicobacter pylori hpEurope strain N6.Journal of bacteriology · 2012Article
- Natural transformation of an engineered Helicobacter pylori strain deficient in type II restriction endonucleases.Journal of bacteriology · 2012Article
- The nucleotide excision repair (NER) system of Helicobacter pylori: role in mutation prevention and chromosomal import patterns after natural transformation.BMC microbiology · 2012Article
- Whole genome sequence of Treponema pallidum ssp. pallidum, strain Mexico A, suggests recombination between yaws and syphilis strains.PLoS neglected tropical diseases · 2012Article
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Helicobacter pylori colonizes the gastric mucosa of half of the human population, causing gastritis, ulcers, and cancer. H. pylori is naturally competent for transformation by exogenous DNA, and recombination during mixed infections of one stomach with multiple H. pylori strains generates extensive allelic diversity. We developed an in vitro transformation protocol to study genomic imports after natural transformation of H. pylori. The mean length of imported fragments was dependent on the combination of donor and recipient strain and varied between 1294 bp and 3853 bp. In about 10% of recombinant clones, the imported fragments of donor DNA were interrupted by short interspersed sequences of the recipient (ISR) with a mean length of 82 bp. 18 candidate genes were inactivated in order to identify genes involved in the control of import length and generation of ISR. Inactivation of the antimutator glycosylase MutY increased the length of imports, but did not have a significant effect on ISR frequency. Overexpression of mutY strongly increased the frequency of ISR, indicating that MutY, while not indispensable for ISR formation, is part of at least one ISR-generating pathway. The formation of ISR in H. pylori increases allelic diversity, and contributes to the uniquely low linkage disequilibrium characteristic of this pathogen.
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