ReviewNature clinical practice. Cardiovascular medicine2009
Adverse cardiovascular effects of air pollution.
Review in Nature clinical practice. Cardiovascular medicine, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 254 papers, 9 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
254 citing papers in PubMed, 9 syntheses or guidelines pooled it, 775 citations in OpenAlex.
- Short-term Exposure to Air Pollution and Ischemic Stroke: A Systematic Review and Meta-analysis.Neurology · 2023Pooled it
- Adverse health effects associated with household air pollution: a systematic review, meta-analysis, and burden estimation study.The Lancet. Global health · 2020Pooled it
- Dietary Polyphenols-Important Non-Nutrients in the Prevention of Chronic Noncommunicable Diseases. A Systematic Review.Nutrients · 2019Pooled it
- Global Association of Air Pollution and Cardiorespiratory Diseases: A Systematic Review, Meta-Analysis, and Investigation of Modifier Variables.American journal of public health · 2018Pooled it
- Short-Term Exposure to Air Pollution and Cardiac Arrhythmia: A Meta-Analysis and Systematic Review.International journal of environmental research and public health · 2016Pooled it
- Short-term exposure to particulate air pollution and risk of myocardial infarction: a systematic review and meta-analysis.Environmental science and pollution research international · 2015Pooled it
- Short term exposure to air pollution and stroke: systematic review and meta-analysis.BMJ (Clinical research ed.) · 2015Pooled it
- Outdoor fine particles and nonfatal strokes: systematic review and meta-analysis.Epidemiology (Cambridge, Mass.) · 2014Pooled it
- Global association of air pollution and heart failure: a systematic review and meta-analysis.Lancet (London, England) · 2013Pooled it
- Human exposure to diesel exhaust induces CYP1A1 expression and AhR activation without a coordinated antioxidant response.Particle and fibre toxicology · 2023Trial
- Respiratory effects of fine and ultrafine particles from indoor sources--a randomized sham-controlled exposure study of healthy volunteers.International journal of environmental research and public health · 2014Trial
- Imaging and safety profiling of inhaled siRNA RyR2 in human respiratory models.Archives of toxicology · 2026Article
- Microplastics and Nanoplastics in Cardiovascular Disease: An Emerging Cardiovascular Risk Factor.Cardiovascular toxicology · 2026Review
- Methodological and Pathophysiological Considerations in Obesity-Associated Thrombosis.International journal of molecular sciences · 2026Review
- Many Moving Parts: New Transplant Allocation Models Are Associated With Increased Organ Travel and Potential Climate Implications.Clinical transplantation · 2025Article
- Toxicity Impacts of Trace-Level of F-53B in Atmospheric Particles: Implications for Low-Exposure Risk Assessment.Environmental science & technology · 2025Article
- Assessing the benefits of hypothetical air pollution reduction scenarios on stroke in belgium: a g-computation approach.BMC medical research methodology · 2025Article
- A Mean Field Poisson-Boltzmann Theory Assessment of Copper Oxide Nanosheets Interaction Potential in Physiological Fluids.Nanomaterials (Basel, Switzerland) · 2025Article
- Exposure to Air Pollution and Changes in Resting Blood Pressure from Morning to Evening: The MobiliSense Study.International journal of environmental research and public health · 2025Article
- Lung cell toxicological effects of 3D printer aerosolized filament byproducts.Environmental science and pollution research international · 2025Article
194 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 3 institutions in 4 countries.
Funding
Abstract
Air pollution is increasingly recognized as an important and modifiable determinant of cardiovascular disease in urban communities. Acute exposure has been linked to a range of adverse cardiovascular events including hospital admissions with angina, myocardial infarction, and heart failure. Long-term exposure increases an individual's lifetime risk of death from coronary heart disease. The main arbiter of these adverse health effects seems to be combustion-derived nanoparticles that incorporate reactive organic and transition metal components. Inhalation of this particulate matter leads to pulmonary inflammation with secondary systemic effects or, after translocation from the lung into the circulation, to direct toxic cardiovascular effects. Through the induction of cellular oxidative stress and proinflammatory pathways, particulate matter augments the development and progression of atherosclerosis via detrimental effects on platelets, vascular tissue, and the myocardium. These effects seem to underpin the atherothrombotic consequences of acute and chronic exposure to air pollution. An increased understanding of the mediators and mechanisms of these processes is necessary if we are to develop strategies to protect individuals at risk and reduce the effect of air pollution on cardiovascular disease.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.