ReviewLaboratory investigation; a journal of technical methods and pathology2009
Recent advances in the renal-skeletal-gut axis that controls phosphate homeostasis.
Review in Laboratory investigation; a journal of technical methods and pathology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
29 citing papers in PubMed, 68 citations in OpenAlex.
- DimericeLife · 2025Article
- Effects of the Interaction between Dietary Vitamin DAnimals : an open access journal from MDPI · 2024Article
- Ethnic and seasonal variations in FGF-23 and markers of chronic kidney disease-mineral and bone disorder.Clinical kidney journal · 2024Article
- Hypertensive heart disease: risk factors, complications and mechanisms.Frontiers in cardiovascular medicine · 2023Review
- Skin Sodium and Blood Pressure Regulation.Electrolyte & blood pressure : E & BP · 2022Review
- Dietary Supplementation of Calcium Propionate and Calcium Butyrate Improves Eggshell Quality of Laying Hens in the Late Phase of Production.The journal of poultry science · 2022Article
- FAM20C Overview: Classic and Novel Targets, Pathogenic Variants and Raine Syndrome Phenotypes.International journal of molecular sciences · 2021Review
- In Vivo Toxicity and In Vitro Solubility Assessment of Pre-Treated Struvite as A Potential Alternative Phosphorus Source in Animal Feed.Animals : an open access journal from MDPI · 2019Article
- Skin Sodium and Hypertension: a Paradigm Shift?Current hypertension reports · 2018Review
- Effect of variations in dietary Pi intake on intestinal Pi transporters (NaPi-IIb, PiT-1, and PiT-2) and phosphate-regulating factors (PTH, FGF-23, and MEPE).Pflugers Archiv : European journal of physiology · 2018Article
- Article
- MEPE Localization in the Craniofacial Complex and Function in Tooth Dentin Formation.The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society · 2016Article
- Physiology of Intestinal Absorption and Secretion.Best practice & research. Clinical gastroenterology · 2016Review
- A short story of Klotho and FGF23: a deuce of dark side or the savior?International urology and nephrology · 2014Review
- The chicken or the egg: PHEX, FGF23 and SIBLINGs unscrambled.Cell biochemistry and function · 2012Review
- The role of vitamin D in the FGF23, klotho, and phosphate bone-kidney endocrine axis.Reviews in endocrine & metabolic disorders · 2012Review
- FGF23 analysis of a Chinese family with autosomal dominant hypophosphatemic rickets.Journal of bone and mineral metabolism · 2012Article
- Regulation of bone-renal mineral and energy metabolism: the PHEX, FGF23, DMP1, MEPE ASARM pathway.Critical reviews in eukaryotic gene expression · 2012Review
- Liver X receptor-activating ligands modulate renal and intestinal sodium-phosphate transporters.Kidney international · 2011Article
- Phosphatonins: new hormones involved in numerous inherited bone disorders.Clinical cases in mineral and bone metabolism : the official journal of the Italian Society of Osteoporosis, Mineral Metabolism, and Skeletal Diseases · 2011Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Under physiological conditions, homeostasis of inorganic phosphate (Pi) is tightly controlled by a network of increasingly more complex interactions and direct or indirect feedback loops among classical players, such as vitamin D (1,25(OH)2D3), parathyroid hormone (PTH), intestinal and renal phosphate transporters, and the recently described phosphatonins and minhibins. A series of checks and balances offsets the effects of 1,25(OH)2D3 and PTH to enable fine-tuning of intestinal and renal Pi absorptive capacity and bone resorption and mineralization. The latter include PHEX, FGF-23, MEPE, DMP1, and secreted FRP4. Despite this large number of regulatory components with complex interactions, the system has limited redundancy and is prone to dysregulation under pathophysiological conditions. This article reviews and synthesizes recent advances to present a new model of Pi homeostasis.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.