ReviewOncogene2008
Upsides and downsides to polarity and asymmetric cell division in leukemia.
Review in Oncogene, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
22 citing papers in PubMed, 31 citations in OpenAlex.
- Bone marrow-inspired DLL1-presenting microparticles enhance asymmetric division and maintenance of mouse hematopoietic stem and progenitor cells.Stem cell reports · 2026Article
- Article
- The SF3B1Journal of experimental & clinical cancer research : CR · 2022Article
- The polarity protein PARD3 and cancer.Oncogene · 2021Review
- Somatic Sex: On the Origin of Neoplasms With Chromosome Counts in Uneven Ploidy Ranges.Frontiers in cell and developmental biology · 2021Article
- Acute Myeloid Leukemia: Aging and Epigenetics.Cancers · 2019Review
- Upsetting the Balance: When Viruses Manipulate Cell Polarity Control.Journal of molecular biology · 2018Review
- Cell Polarity and Division Symmetry Analyses in Transformed Blood Cells.Methods in molecular biology (Clifton, N.J.) · 2018Article
- The cell polarity determinant CDC42 controls division symmetry to block leukemia cell differentiation.Blood · 2017Article
- Planar cell polarity gene expression correlates with tumor cell viability and prognostic outcome in neuroblastoma.BMC cancer · 2016Article
- Scribble acts as an oncogene in Eμ-myc-driven lymphoma.Oncogene · 2016Article
- Polarized cells, polarized views: asymmetric cell division in hematopoietic cells.Frontiers in immunology · 2014Review
- Lethal giant larvae 1 tumour suppressor activity is not conserved in models of mammalian T and B cell leukaemia.PloS one · 2014Article
- Article
- Human tumour viruses and the deregulation of cell polarity in cancer.Nature reviews. Cancer · 2012Review
- Article
- Article
- Participation of the cell polarity protein PALS1 to T-cell receptor-mediated NF-κB activation.PloS one · 2011Article
- Immature T-cell clustering and efficient differentiation require the polarity protein Scribble.Proceedings of the National Academy of Sciences of the United States of America · 2011Article
- Concise review: polarity in stem cells, disease, and aging.Stem cells (Dayton, Ohio) · 2010Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The notion that polarity regulators can act as tumor suppressors in epithelial cells is now well accepted. The function of these proteins in lymphocytes is less well explored, and their possible function as suppressors of leukemia has had little attention so far. We review the literature on lymphocyte polarity and the growing recognition that polarity proteins have an important function in lymphocyte function. We then describe molecular relationships between the polarity network and signaling pathways that have been implicated in leukemogenesis, which suggest mechanisms by which the polarity network might impact on leukemogenesis. We particularly focus on the possibility that disruption of polarity might alter asymmetric cell division (ACD), and that this might be a leukemia-initiating event. We also explore the converse possibility that leukemic stem cells might be produced or maintained by ACD, and therefore that Dlg, Scribble and Lgl might be important regulators of this process.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.