ReviewOncogene2008
Biomechanical regulation of cell orientation and fate.
Review in Oncogene, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 56 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
56 citing papers in PubMed, 141 citations in OpenAlex.
- Spatial relationships between vinculin tension and actin at cell adhesions define cell colony positioning and identity.Biophysical journal · 2026Article
- Reorganizing chromatin by cellular deformation.Current opinion in cell biology · 2024Review
- Inhibition of Renin Expression Is Regulated by an Epigenetic Switch From an Active to a Poised State.Hypertension (Dallas, Tex. : 1979) · 2024Article
- Mechanosensitive hormone signaling promotes mammary progenitor expansion and breast cancer risk.Cell stem cell · 2024Article
- Invasion and Secondary Site Colonization as a Function of In Vitro Primary Tumor Matrix Stiffness: Breast to Bone Metastasis.Advanced healthcare materials · 2023Article
- Aligned forces: Origins and mechanisms of cancer dissemination guided by extracellular matrix architecture.Current opinion in cell biology · 2021Review
- Article
- Review
- Regulation and mechanism of YAP/TAZ in the mechanical microenvironment of stem cells (Review).Molecular medicine reports · 2021Review
- Effect of alginate matrix engineered to mimic the pancreatic microenvironment on encapsulated islet function.Biotechnology and bioengineering · 2021Article
- The protective effect of betacellulin against acute pancreatitis is ERBB4 dependent.Journal of gastroenterology · 2020Article
- Tumour Initiation: a Discussion on Evidence for a "Load-Trigger" Mechanism.Cell biochemistry and biophysics · 2019Review
- Advances and Current Challenges in IntestinalFrontiers in bioengineering and biotechnology · 2019Review
- The Effect of Mammary Extracellular Matrix in Controlling Oral and Mammary Cancer CellsAsian Pacific journal of cancer prevention : APJCP · 2018Article
- Model of vascular desmoplastic multispecies tumor growth.Journal of theoretical biology · 2017Article
- Role of LOXL2 in the epithelial-mesenchymal transition and colorectal cancer metastasis.Oncotarget · 2017Article
- Keloid progression: a stiffness gap hypothesis.International wound journal · 2017Article
- The role of shear stress and altered tissue properties on endothelial to mesenchymal transformation and tumor-endothelial cell interaction.Biomicrofluidics · 2017Article
- Myofibroblast repair mechanisms post-inflammatory response: a fibrotic perspective.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2017Review
- Dynamic Microenvironment Induces Phenotypic Plasticity of Esophageal Cancer Cells Under Flow.Scientific reports · 2016Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Biomechanical regulation of tumor phenotypes have been noted for several decades, yet the function of mechanics in the co-evolution of the tumor epithelium and altered cancer extracellular matrix has not been appreciated until fairly recently. In this review, we examine the dynamic interaction between the developing epithelia and the extracellular matrix, and discuss how similar interactions are exploited by the genetically modified epithelium during tumor progression. We emphasize the process of mechanoreciprocity, which is a phenomenon observed during epithelial transformation, in which tension generated within the extracellular microenvironment induce and cooperate with opposing reactive forces within transformed epithelium to drive tumor progression and metastasis. We highlight the importance of matrix remodeling, and present a new, emerging paradigm that underscores the importance of tissue morphology as a key regulator of epithelial cell invasion and metastasis.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.