ArticleBreast disease2008
Support for the selective chromatid segregation hypothesis advanced for the mechanism of left-right body axis development in mice.
Article in Breast disease, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
22 citing papers in PubMed, 31 citations in OpenAlex.
- The Inherent Asymmetry of DNA Replication.Annual review of cell and developmental biology · 2017Review
- Split hand/foot malformation genetics supports the chromosome 7 copy segregation mechanism for human limb development.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2016Review
- From cytoskeletal dynamics to organ asymmetry: a nonlinear, regulative pathway underlies left-right patterning.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2016Review
- Conserved roles for cytoskeletal components in determining laterality.Integrative biology : quantitative biosciences from nano to macro · 2016Review
- Mahogunin-mediated α-tubulin ubiquitination via noncanonical K6 linkage regulates microtubule stability and mitotic spindle orientation.Cell death & disease · 2014Article
- Left-right patterning in Xenopus conjoined twin embryos requires serotonin signaling and gap junctions.The International journal of developmental biology · 2014Article
- Selective chromatid segregation mechanism invoked for the human congenital mirror hand movement disorder development by RAD51 mutations: a hypothesis.International journal of biological sciences · 2014Review
- It's never too early to get it Right: A conserved role for the cytoskeleton in left-right asymmetry.Communicative & integrative biology · 2013Article
- A unified model for left-right asymmetry? Comparison and synthesis of molecular models of embryonic laterality.Developmental biology · 2013Review
- Unbiased segregation of fission yeast chromosome 2 strands to daughter cells.Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology · 2013Review
- A CO-FISH assay to assess sister chromatid segregation patterns in mitosis of mouse embryonic stem cells.Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology · 2013Article
- Micropatterning of cells reveals chiral morphogenesis.Stem cell research & therapy · 2013Review
- Implication of the Strand-Specific Imprinting and Segregation Model: IntegratingHereditary genetics : current research · 2013Article
- Defining the epigenetic mechanism of asymmetric cell division of Schizosaccharomyces japonicus yeast.Genetics · 2013Article
- Early, nonciliary role for microtubule proteins in left-right patterning is conserved across kingdoms.Proceedings of the National Academy of Sciences of the United States of America · 2012Article
- Left-right symmetry breaking in mice by left-right dynein may occur via a biased chromatid segregation mechanism, without directly involving the Nodal gene.Frontiers in oncology · 2012Article
- Functional characterization of stem cell activity in the mouse mammary gland.Stem cell reviews and reports · 2011Review
- Article
- Far from solved: a perspective on what we know about early mechanisms of left-right asymmetry.Developmental dynamics : an official publication of the American Association of Anatomists · 2010Review
- A proposal for re-defining the way the aetiology of schizophrenia and bipolar human psychiatric diseases is investigated.Journal of biosciences · 2010Article
Corrections and comments
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Authors and funding
1 author at 1 institution in 1 country.
Funding
Abstract
The somatic DNA strand-specific imprinting to effect gene regulation and selective chromatid segregation model was previously proposed to produce developmentally nonequivalent sister cells in mitosis. Such a mechanism might explain generation of stem-cell pattern of cell division in eukaryotes. The developmentally controlled process involves a pair of homologous chromosomes at a specific cell division to establish embryonic left-right body axis asymmetry. As a result, visceral organs in the two sides of vertebrate's body develop asymmetrically. The model was specifically proposed to explain the well-known axis randomization phenotype of the left-right dynein mutant mice where one-half of animals develop with standard visceral organ's positioning and the balance develops with the inverted arrangement. The model postulated that the specific dynein, a microtubule-based molecular motor protein, promotes the selective chromatid segregation process in mitosis. Thus, random segregation involving sister chromatids of a pair of specific chromosomes leads to axis randomization of the mutant. Moreover, the model uniquely predicts that 50 percent mutant embryos should produce symmetrical cell divisions because of random segregation; consequently, their either visceral side would develop as mirror image of the other side resulting in embryonic lethality. In view of this prediction, validity of prominent body axis-determination models is scrutinized here. Results supporting the cell-type regulated chromosome 6 and chromosome 7 selective chromatids segregation phenomenon existing in mouse cells are reviewed. Published results with the mutant mice are consistent with the chromosome segregation model for axis determination.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.