ArticleParasitology research1991
The infection characteristics of a South African isolate of Schistosoma mansoni: a comparison with a Puerto Rican isolate in BALB/c mice and Mastomys coucha.
Article in Parasitology research, 1991. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
3 citing papers in PubMed.
- Intra-specific variations in Schistosoma mansoni and their possible contribution to inconsistent virulence and diverse clinical outcomes.PLoS neglected tropical diseases · 2024Article
- A Study of the Granulomatous Responses Induced by Different Strains of Schistosoma mansoni.Interdisciplinary perspectives on infectious diseases · 2012Article
- An unlikely partnership: parasites, concomitant immunity and host defence.Proceedings. Biological sciences · 2001Article
Corrections and comments
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The infection characteristics of a South African (RSA) laboratory isolate of Schistosoma mansoni were compared with those of a widely studied Puerto Rican (PR) isolate in BALB/c mice and Mastomys coucha over the period of 5-12 weeks after infection. The infectivity, maturation and, in particular, the fecundity of the two schistosomes were found to differ markedly. Tissue egg-accumulation rates of the RSA strain were substantially lower than those of the PR strain. Although the maturation of both parasite strains was somewhat delayed in M. coucha, the characteristics of each was essentially consistent in both rodent hosts. Notwithstanding the possible influence of prolonged laboratory passage on the behaviour of schistosome isolates, the results of the present study are nevertheless considered to support the idea that parasite strain differences may, to some extent, account for regional variations in the morbidity of intestinal schistosomiasis. The need to be cognizant of the characteristics of individual host-parasite combinations when comparing different schistosome species and strains, particularly with respect to both their abilities to elicit immunopathology and induce concomitant immunity and their susceptibilities to chemotherapy, is highlighted.
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