ArticleHypertension (Dallas, Tex. : 1979)2009
Genetic effect on blood pressure is modulated by age: the Hypertension Genetic Epidemiology Network Study.
Article in Hypertension (Dallas, Tex. : 1979), 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers, 3 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
33 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Genome-wide pleiotropy analysis identifies novel blood pressure variants and improves its polygenic risk scores.Genetic epidemiology · 2022Pooled it
- Linkage analysis incorporating gene-age interactions identifies seven novel lipid loci: the Family Blood Pressure Program.Atherosclerosis · 2014Pooled it
- Lack of association between alpha-adducin G460W polymorphism and hypertension: evidence from a case-control study and a meta-analysis.Journal of human hypertension · 2010Pooled it
- Genome-wide linkage and positional association study of blood pressure response to dietary sodium intervention: the GenSalt Study.American journal of epidemiology · 2012Trial
- Hiding in plain sight: uncovering the genetic basis of complex phenotypes through low-risk groups.Genetics · 2026Article
- Life stage-specific heterogeneity in the effects of adiposity transition on hypertension incidence and resolution.International journal of obesity (2005) · 2026Article
- Genetics of hypertension in populations affected by the Aral Sea ecological crisis: A case-control study.PloS one · 2026Article
- LDER-GE estimates phenotypic variance component of gene-environment interactions in human complex traits accurately with GE interaction summary statistics and full LD information.Briefings in bioinformatics · 2024Article
- The impact of age on genetic risk for common diseases.PLoS genetics · 2021Article
- Genetically determined NLRP3 inflammasome activation associates with systemic inflammation and cardiovascular mortality.European heart journal · 2021Article
- Replication of European hypertension associations in a case-control study of 9,534 African Americans.PloS one · 2021Article
- Article
- Applicability of Precision Medicine Approaches to Managing Hypertension in Rural Populations.Journal of personalized medicine · 2018Article
- Methods to evaluate rare variants gene-age interaction for triglycerides.BMC proceedings · 2018Article
- Rare variants in fox-1 homolog A (RBFOX1) are associated with lower blood pressure.PLoS genetics · 2017Article
- Article
- Three Approaches to Modeling Gene-Environment Interactions in Longitudinal Family Data: Gene-Smoking Interactions in Blood Pressure.Genetic epidemiology · 2016Article
- Influence of Smoking Status and Intensity on Discovery of Blood Pressure Loci Through Gene-Smoking Interactions.Genetic epidemiology · 2015Article
- Kernel Approach for Modeling Interaction Effects in Genetic Association Studies of Complex Quantitative Traits.Genetic epidemiology · 2015Article
- Single nucleotide polymorphism-single nucleotide polymorphism interactions among inflammation genes in the genetic architecture of blood pressure in the Framingham Heart Study.American journal of hypertension · 2015Article
Corrections and comments
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Authors and funding
8 authors.
Funding
Abstract
Genome-wide linkage analysis was performed for systolic and diastolic blood pressures in the Hypertension Genetic Epidemiology Network. We investigated the role of gene-age interactions using a recently developed variance components method that incorporates age variation in genetic effects. Substantially improved linkage evidence, in terms of both the number of linkage peaks and their significance levels, was observed. Twenty-six linkage peaks were identified with maximum logarithm of odds scores ranging between 3.0 and 4.6, 15 of which were cross-validated by the literature. The chromosomal region 1p36 that showed the highest logarithm of odds score in our study was found to be supported by evidence from 3 studies. The new method also led to vastly improved validation across ethnic groups. Ten of the 15 supported linkage peaks were cross-validated between 2 different ethnic groups, and 2 peaks on chromosomal region 1q31 and 16p11 were validated in 3 ethnic groups. In conclusion, this investigation demonstrates that genetic effects on blood pressure vary by age. The improved genetic linkage results presented here should help to identify the specific genetic variants that explain the observed results.
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