ArticleHypertension (Dallas, Tex. : 1979)2009
Tonic glutamatergic input in the rostral ventrolateral medulla is increased in rats with chronic heart failure.
Article in Hypertension (Dallas, Tex. : 1979), 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
39 citing papers in PubMed, 55 citations in OpenAlex.
- Neurocardiology: Brain-Heart Interactions in the Heart.MedComm · 2026Review
- The Rostral Ventrolateral Medulla Input to Central Amygdala Regulates Anxiety-Like Behaviors in Mice for Chronic Light Exposure.CNS neuroscience & therapeutics · 2026Article
- Neural control of the circulation during exercise in heart failure with reduced and preserved ejection fraction.American journal of physiology. Heart and circulatory physiology · 2023Review
- C-type natriuretic peptide (CNP) in the paraventricular nucleus-mediated renal sympatho-inhibition.Frontiers in physiology · 2023Article
- DPP3: From biomarker to therapeutic target of cardiovascular diseases.Frontiers in cardiovascular medicine · 2022Review
- Sex-dependent development of enhanced sympathoexcitation in sedentary versus physically active rats.The Journal of physiology · 2021Article
- Neuroplasticity in N-methyl-d-aspartic acid receptor signaling in subregions of the rat rostral ventrolateral medulla following sedentary versus physically active conditions.The Journal of comparative neurology · 2021Article
- Subregional differences in GABAThe Journal of comparative neurology · 2020Article
- Cardiovascular responses produced by resistin injected into paraventricular nucleus mediated by the glutamatergic and CRFergic transmissions within rostral ventrolateral medulla.Iranian journal of basic medical sciences · 2020Article
- Central blockade of the AT1 receptor attenuates pressor effects via reduction of glutamate release and downregulation of NMDA/AMPA receptors in the rostral ventrolateral medulla of rats with stress-induced hypertension.Hypertension research : official journal of the Japanese Society of Hypertension · 2019Article
- Sympathoexcitation by hypothalamic paraventricular nucleus neurons projecting to the rostral ventrolateral medulla.The Journal of physiology · 2018Article
- Rostral Ventrolateral Medulla and Hypertension.Hypertension (Dallas, Tex. : 1979) · 2018Review
- Development of manganese-enhanced magnetic resonance imaging of the rostral ventrolateral medulla of conscious rats: Importance of normalization and comparison with other regions of interest.NMR in biomedicine · 2018Article
- Overexpression of ß-Arrestin1 in the Rostral Ventrolateral Medulla Downregulates Angiotensin Receptor and Lowers Blood Pressure in Hypertension.Frontiers in physiology · 2018Article
- Sedentary conditions and enhanced responses to GABA in the RVLM: role of the contralateral RVLM.American journal of physiology. Regulatory, integrative and comparative physiology · 2017Article
- Vasopressin V1a receptors mediate the hypertensive effects of [PyrThe Journal of physiology · 2017Article
- Cardiac sympathetic afferent reflex control of cardiac function in normal and chronic heart failure states.The Journal of physiology · 2017Article
- The activation of the kynurenine pathway in a rat model with renovascular hypertension.Experimental biology and medicine (Maywood, N.J.) · 2017Article
- Enhancement in Tonically Active Glutamatergic Inputs to the Rostral Ventrolateral Medulla Contributes to Neuropathic Pain-Induced High Blood Pressure.Neural plasticity · 2017Article
- Exercise training preserves vagal preganglionic neurones and restores parasympathetic tonus in heart failure.The Journal of physiology · 2016Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 1 institution in 2 countries.
Funding
Abstract
Chronic heart failure (CHF) is characterized by increased sympathetic tone. The glutamatergic input in the rostral ventrolateral medulla (RVLM), which is a key region involved in sympathetic outflow, seems not to be involved in the generation of sympathetic tone in the normal state. The aim of this study was to determine the role of the RVLM glutamate receptors in the generation of sympathetic tone in CHF. CHF was produced by coronary artery ligation. Bilateral microinjection of the glutamate receptor antagonist kynurenic acid, the N-methyl-d-aspartate (NMDA) receptor antagonist D-2-amino-5-phosphonopentanoate, or the non-NMDA receptor antagonist 6-cyano-7-nitroquinoxaline-2,3-dione into the RVLM dose-dependently reduced resting blood pressure and renal sympathetic nerve activity in CHF but not in sham rats. Picoinjection of kynurenic acid (100 pmol in 5 nL) significantly decreased the basal discharge by 47% in 25 RVLM presympathetic neurons in CHF rats. In contrast, kynurenic acid had no effect on the discharge in all 22 of the RVLM presympathetic neurons tested in sham rats. These data suggest that upregulated glutamate receptors, including NMDA and non-NMDA, in the RVLM are involved in tonic control of elevated sympathetic tone in CHF.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.