ArticleRNA (New York, N.Y.)2009
The 5' external transcribed spacer in mouse ribosomal RNA contains two cleavage sites.
Article in RNA (New York, N.Y.), 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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Who cites it
29 citing papers in PubMed, 46 citations in OpenAlex.
- RiboCop surveils pre-rRNA processing by Dicer in cellular quiescence.bioRxiv : the preprint server for biology · 2025Article
- Yeast pre-rRNA is processed at the A' site.microPublication biology · 2025Article
- Mouse Oocytes, A Complex Single Cell Transcriptome.Frontiers in cell and developmental biology · 2022Article
- Elimination of 01/A'-A0 pre-rRNA processing by-product in human cells involves cooperative action of two nuclear exosome-associated nucleases: RRP6 and DIS3.RNA (New York, N.Y.) · 2018Article
- Iron-dependent cleavage of ribosomal RNA during oxidative stress in the yeastThe Journal of biological chemistry · 2018Article
- Ribosomal RNA Biogenesis and Its Response to Chilling Stress inPlant physiology · 2018Article
- Endonucleolytic cleavage in the expansion segment 7 of 25S rRNA is an early marker of low-level oxidative stress in yeast.The Journal of biological chemistry · 2017Article
- Cooling-induced SUMOylation of EXOSC10 down-regulates ribosome biogenesis.RNA (New York, N.Y.) · 2016Article
- SIRT7-dependent deacetylation of the U3-55k protein controls pre-rRNA processing.Nature communications · 2016Article
- Article
- hUTP24 is essential for processing of the human rRNA precursor at site A1, but not at site A0.RNA biology · 2015Article
- Hira-mediated H3.3 incorporation is required for DNA replication and ribosomal RNA transcription in the mouse zygote.Developmental cell · 2014Article
- The roles of SSU processome components and surveillance factors in the initial processing of human ribosomal RNA.RNA (New York, N.Y.) · 2014Article
- Article
- Inhibition of U4 snRNA in human cells causes the stable retention of polyadenylated pre-mRNA in the nucleus.PloS one · 2014Article
- Two orthogonal cleavages separate subunit RNAs in mouse ribosome biogenesis.Nucleic acids research · 2014Article
- Analysis of rRNA processing and translation in mammalian cells using a synthetic 18S rRNA expression system.Nucleic acids research · 2012Article
- Nuclear noncoding RNA surveillance: is the end in sight?Trends in genetics : TIG · 2012Review
- Self-circularizing 5'-ETS RNAs accumulate along with unprocessed pre ribosomal RNAs in growth-stressed Entamoeba histolytica.Scientific reports · 2012Article
- The Fate of the Nucleolus during Mitosis: Comparative Analysis of Localization of Some Forms of Pre-rRNA by Fluorescent in Situ Hybridization in NIH/3T3 Mouse Fibroblasts.Acta naturae · 2011Article
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
The 5' external transcribed spacer (5'ETS) is critical for 18S rRNA formation and is the longest noncoding region in a ribosomal RNA transcript. Here we show that processing in mouse 5'ETS involves two cleavage events. Processing at site A' corresponds to the previously described "primary cleavage," which precedes other processing steps. Processing at the novel site A0 occurs 1 kb downstream from A' yielding two new rRNA precursors: 43S and 29S. The excised 5'-A' and A'-A0 fragments are rapidly degraded under normal conditions. Depletion of the exosome component EXOSC10/PM-Scl100 (ortholog of yeast Rrp6p) results in a strong accumulation of the A'-A0 spacer fragment in mouse cells. We discuss the finding of a second processing site in mammalian 5'ETS in relation to the involvement of the U3 snoRNA in pre-rRNA processing and present a revised map of the mouse 18S rRNA processing pathway.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.