ArticleMolecular and cellular biology2009
Of bars and rings: Hof1-dependent cytokinesis in multiseptated hyphae of Ashbya gossypii.
Article in Molecular and cellular biology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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19 citing papers in PubMed, 39 citations in OpenAlex.
- Septins and cytokinesis in the polymorphic fungus Aureobasidium pullulans.The Journal of cell biology · 2026Article
- Mitigating transcription noise via protein sharing in syncytial cells.Biophysical journal · 2024Article
- Syncytial Assembly Lines: Consequences of Multinucleate Cellular Compartments for Fungal Protein Synthesis.Results and problems in cell differentiation · 2024Review
- Live-cell imaging of septins and cell polarity proteins in the growing dikaryotic vegetative hypha of the model mushroom Coprinopsis cinerea.Scientific reports · 2023Article
- A gene duplication of a septin reveals a developmentally regulated filament length control mechanism.The Journal of cell biology · 2023Article
- Sporulation inJournal of fungi (Basel, Switzerland) · 2020Review
- Dynamics of the establishment of multinucleate compartments in Fusarium oxysporum.Eukaryotic cell · 2015Article
- Fungal model systems and the elucidation of pathogenicity determinants.Fungal genetics and biology : FG & B · 2014Review
- Genomes of Ashbya fungi isolated from insects reveal four mating-type loci, numerous translocations, lack of transposons, and distinct gene duplications.G3 (Bethesda, Md.) · 2013Article
- Article
- Hof1 and Rvs167 have redundant roles in actomyosin ring function during cytokinesis in budding yeast.PloS one · 2013Article
- Heterogeneity in mitochondrial morphology and membrane potential is independent of the nuclear division cycle in multinucleate fungal cells.Eukaryotic cell · 2012Article
- IQGAP Family Members in Yeast, Dictyostelium, and Mammalian Cells.International journal of cell biology · 2012Article
- Nuclear and genome dynamics in multinucleate ascomycete fungi.Current biology : CB · 2011Review
- Regulation of exit from mitosis in multinucleate Ashbya gossypii cells relies on a minimal network of genes.Molecular biology of the cell · 2011Article
- The fungal type II myosin in Penicillium marneffei, MyoB, is essential for chitin deposition at nascent septation sites but not actin localization.Eukaryotic cell · 2011Article
- Septins from the phytopathogenic fungus Ustilago maydis are required for proper morphogenesis but dispensable for virulence.PloS one · 2010Article
- Mobility, microtubule nucleation and structure of microtubule-organizing centers in multinucleated hyphae of Ashbya gossypii.Molecular biology of the cell · 2010Article
- The Sir2-Sum1 complex represses transcription using both promoter-specific and long-range mechanisms to regulate cell identity and sexual cycle in the yeast Kluyveromyces lactis.PLoS genetics · 2009Article
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2 authors at 1 institution in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
We analyzed the development of multiple septa in elongated multinucleated cells (hyphae) of the filamentous ascomycete Ashbya gossypii in which septation is apparently uncoupled from nuclear cycles. A key player for this compartmentalization is the PCH protein Hof1. Hyphae that are lacking this protein form neither actin rings nor septa but still elongate at wild-type speed. Using in vivo fluorescence microscopy, we present for the first time the coordination of cytokinesis and septation in multiseptated and multinucleated cells. Hof1, the type II myosin Myo1, the landmark protein Bud3, and the IQGAP Cyk1 form collars of cortical bars already adjacent to hyphal tips, thereby marking the sites of septation. While hyphae continue to elongate, these proteins gradually form cortical rings. This bar-to-ring transition depends on Hof1 and Cyk1 but not Myo1 and is required for actin ring assembly. The Fes/CIP4 homology (FCH) domain of Hof1 ensures efficient localization of Hof1, whereas ring integrity is conferred by the Src homology 3 (SH3) domain. Up to several hours after site selection, actin ring contraction leads to membrane invagination and subsequent cytokinesis. Simultaneously, a septum forms between the adjacent hyphal compartments, which do not separate. During evolution, A. gossypii lost the homologs of two enzymes essential for cell separation in Saccharomyces cerevisiae.
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