ArticleCerebral cortex (New York, N.Y. : 1991)2009
Synaptogenesis in purified cortical subplate neurons.
Article in Cerebral cortex (New York, N.Y. : 1991), 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
12 citing papers in PubMed, 25 citations in OpenAlex.
- Article
- Article
- Heterogeneity in Synaptogenic Profile of Astrocytes from Different Brain Regions.Molecular neurobiology · 2018Article
- In vitro and Ex vivo Neurotoxic Effects of Efavirenz are Greater than Those of Other Common Antiretrovirals.Neurochemical research · 2017Article
- Astrocytes Control Synapse Formation, Function, and Elimination.Cold Spring Harbor perspectives in biology · 2015Review
- Expression profiling of mouse subplate reveals a dynamic gene network and disease association with autism and schizophrenia.Proceedings of the National Academy of Sciences of the United States of America · 2013Article
- Mechanisms controlling the guidance of thalamocortical axons through the embryonic forebrain.The European journal of neuroscience · 2012Review
- Hypothesis on the dual origin of the Mammalian subplate.Frontiers in neuroanatomy · 2011Article
- Development of axonal pathways in the human fetal fronto-limbic brain: histochemical characterization and diffusion tensor imaging.Journal of anatomy · 2010Review
- AMPA and metabotropic excitoxicity explain subplate neuron vulnerability.Neurobiology of disease · 2010Article
- Roles of glial cells in synapse development.Cellular and molecular life sciences : CMLS · 2009Review
- Oligodendrocyte development and the onset of myelination in the human fetal brain.Frontiers in neuroanatomy · 2009Article
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2 authors at 2 institutions in 1 country.
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Abstract
An ideal preparation for investigating events during synaptogenesis would be one in which synapses are sparse, but can be induced at will using a rapid, exogenous trigger. We describe a culture system of immunopurified subplate neurons in which synaptogenesis can be triggered, providing the first homogeneous culture of neocortical neurons for the investigation of synapse development. Synapses in immunopurified rat subplate neurons are sparse, and can be induced by a 48-h exposure to feeder layers of neurons and glia, an induction more rapid than any previously reported. Induced synapses are electrophysiologically functional and ultrastructurally normal. Microarray and real-time PCR experiments reveal a new program of gene expression accompanying synaptogenesis. Surprisingly few known synaptic genes are upregulated during the first 24 h of synaptogenesis; Gene Ontology annotation reveals a preferential upregulation of synaptic genes only at a later time. In situ hybridization confirms that some of the genes regulated in cultures are also expressed in the developing cortex. This culture system provides both a means of studying synapse formation in a homogeneous population of cortical neurons, and better synchronization of synaptogenesis, permitting the investigation of neuron-wide events following the triggering of synapse formation.
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