ArticleApplied and environmental microbiology2009
Differential effects of Bifidobacterium pseudolongum strain Patronus and metronidazole in the rat gut.
Article in Applied and environmental microbiology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
12 citing papers in PubMed, 18 citations in OpenAlex.
- Colonized Niche, Evolution and Function Signatures ofFoods (Basel, Switzerland) · 2021Article
- Insight into the intestinal microbiome of farrowing sows following the administration of garlic (Allium sativum) extract and probiotic bacteria cultures under farming conditions.BMC veterinary research · 2020Article
- Longitudinal Investigation of the Gut Microbiota in Goat Kids from Birth to Postweaning.Microorganisms · 2020Article
- Improvement of Cecal Commensal Microbiome Following the Insect Additive into Chicken Diet.Animals : an open access journal from MDPI · 2020Article
- Analysis of the mouse gut microbiome using full-length 16S rRNA amplicon sequencing.Scientific reports · 2016Article
- Colonic Fermentation Promotes Decompression sickness in Rats.Scientific reports · 2016Article
- Impact of the Consumption of Tea Polyphenols on Early Atherosclerotic Lesion Formation and IntestinalFrontiers in nutrition · 2016Article
- Effect of oral administration of metronidazole or prednisolone on fecal microbiota in dogs.PloS one · 2014Article
- Lactobacillus salivarius strain FDB89 induced longevity in Caenorhabditis elegans by dietary restriction.Journal of microbiology (Seoul, Korea) · 2013Article
- Juvenile ferric iron prevents microbiota dysbiosis and colitis in adult rodents.World journal of gastroenterology · 2012Article
- Long-term changes in human colonic Bifidobacterium populations induced by a 5-day oral amoxicillin-clavulanic acid treatment.PloS one · 2012Article
- The effect of the macrolide antibiotic tylosin on microbial diversity in the canine small intestine as demonstrated by massive parallel 16S rRNA gene sequencing.BMC microbiology · 2009Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In the luminal contents of metronidazole-treated rats, there was a dominant Bifidobacterium species. A strain has been isolated, its 16S rRNA gene has been sequenced, and the strain has been named Bifidobacterium pseudolongum strain Patronus. In this study, using an experimental model of healthy rats, the effects of metronidazole treatment and B. pseudolongum strain Patronus administration on the luminal and mucosa-associated microbiota and on gut oxidation processes were investigated. Metronidazole treatment and the daily gavage of rats with B. pseudolongum strain Patronus increased the numbers of bifidobacteria in cecal contents and in cecal mucosa-associated microbiota compared with those in control rats. Metronidazole reduced the colonic oxidative damage to proteins. This is the first evidence that B. pseudolongum strain Patronus exerts an effect on a biomarker of oxidative damage by reducing the susceptibility to oxidation of proteins in the colon and the small bowel. Antioxidant effects of metronidazole could be linked to the bifidobacterial increase but also to other bacterial modifications.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.