Evidence map›Paper›PMID 19028733›Full record

SynthesisBritish journal of sports medicine2009

A systematic review of four injection therapies for lateral epicondylosis: prolotherapy, polidocanol, whole blood and platelet-rich plasma.

D Rabago, T M Best, A E Zgierska, E Zeisig, M Ryan, D Crane

Abstract readSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in British journal of sports medicine, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 57 papers, 6 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
57citing papers in PubMed, 6 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

57 citing papers in PubMed, 6 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Pooled it
  5. Pooled it
  6. Tennis elbow.BMJ clinical evidence · 2011
    Pooled it
  7. Trial
  8. Review
  9. Review
  10. Article
  11. Article
  12. Article
  13. Prolotherapy: Regenerative Medicine for Lateral Epicondylitis.Turkish journal of anaesthesiology and reanimation · 2020
    Article
  14. Article
  15. Article
  16. Ultrasound-Guided Dry Needling of the Healthy Rat Supraspinatus Tendon Elicits Early Healing Without Causing Permanent Damage.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2019
    Article
  17. Article
  18. Article
  19. Ethics, Evidence Based Sports Medicine, and the Use of Platelet Rich Plasma in the English Premier League.Health care analysis : HCA : journal of health philosophy and policy · 2018
    Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

D RabagoUniversity of Wisconsin School of Medicine and Public Health, Department of Family Medicine, 777 S. Mills St, Madison WI 53715, USA. david.rabago@fammed.wisc.edu
T M Best
A E Zgierska
E Zeisig
M Ryan
D Crane

Funding

The Efficacy of Prolotherapy in Osteoarthritic Knee PainK23AT001879 · NCCIH · UNIVERSITY OF WISCONSIN-MADISON · PI RABAGO, DAVID P · 2004 to 2008
$601k
NCCIH NIH HHS K23 AT001879
6 · The paper itself

Abstract

objectiveTo appraise existing evidence for prolotherapy, polidocanol, autologous whole blood and platelet-rich plasma injection therapies for lateral epicondylosis (LE).

designSystematic review. DATA SOURCES: Medline, Embase, CINAHL, Cochrane Central Register of Controlled Trials, Allied and Complementary Medicine. SEARCH STRATEGY: names and descriptors of the therapies and LE. STUDY SELECTION: All human studies assessing the four therapies for LE. MAIN

resultsResults of five prospective case series and four controlled trials (three prolotherapy, two polidocanol, three autologous whole blood and one platelet-rich plasma) suggest each of the four therapies is effective for LE. In follow-up periods ranging from 9 to 108 weeks, studies reported sustained, statistically significant (p<0.05) improvement in visual analogue scale primary outcome pain score measures and disease-specific questionnaires; relative effect sizes ranged from 51% to 94%; Cohen's d ranged from 0.68 to 6.68. Secondary outcomes also improved, including biomechanical elbow function assessment (polidocanol and prolotherapy), presence of abnormalities and increased vascularity on ultrasound (autologous whole blood and polidocanol). Subjects reported satisfaction with therapies on single-item assessments. All studies were limited by small sample size.

conclusionsThere is strong pilot-level evidence supporting the use of prolotherapy, polidocanol, autologous whole blood and platelet-rich plasma injections in the treatment of LE. Rigorous studies of sufficient sample size, assessing these injection therapies using validated clinical, radiological and biomechanical measures, and tissue injury/healing-responsive biomarkers, are needed to determine long-term effectiveness and safety, and whether these techniques can play a definitive role in the management of LE and other tendinopathies.

Indexed as

Platelet-Rich PlasmaBlood Transfusion, AutologousHumansInjectionsNaturopathyPolidocanolPolyethylene GlycolsRandomized Controlled Trials as TopicSclerosing SolutionsTennis ElbowPolidocanolPolyethylene GlycolsSclerosing Solutions

Identifiers

PMID19028733
PMCPMC2755040

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.