ArticleMolecular and cellular neurosciences2009
Neurogenin3 promotes early retinal neurogenesis.
Article in Molecular and cellular neurosciences, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 27 citations in OpenAlex.
- Temporal Transcriptional Regulation of Human Neuronal Differentiation via Forward Programming.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Neurogenin 2 and Neuronal Differentiation 1 Control Proper Development of the Chick Trigeminal Ganglion and Its Nerve Branches.Journal of developmental biology · 2023Article
- A new role of hindbrain boundaries as pools of neural stem/progenitor cells regulated by Sox2.BMC biology · 2016Article
- Article
- The Retinal Pigment Epithelium: a Convenient Source of New Photoreceptor cells?Journal of ophthalmic & vision research · 2014Article
- Photoreceptor-like cells in transgenic mouse eye.Investigative ophthalmology & visual science · 2013Article
- A CRM1-mediated nuclear export signal is essential for cytoplasmic localization of neurogenin 3 in neurons.PloS one · 2013Article
- NEUROG3 is a critical downstream effector for STAT3-regulated differentiation of mammalian stem and progenitor spermatogonia.Biology of reproduction · 2012Article
- Production of high-titer RCAS retrovirus.Methods in molecular biology (Clifton, N.J.) · 2012Article
- Genetic heterogeneity for recessively inherited congenital cataract microcornea with corneal opacity.Investigative ophthalmology & visual science · 2011Article
- Estradiol meets notch signaling in developing neurons.Frontiers in endocrinology · 2011Article
- Formin1 mediates the induction of dendritogenesis and synaptogenesis by neurogenin3 in mouse hippocampal neurons.PloS one · 2011Article
- Generating retinal neurons by reprogramming retinal pigment epithelial cells.Expert opinion on biological therapy · 2010Review
- Neurog2 controls the leading edge of neurogenesis in the mammalian retina.Developmental biology · 2010Article
- Neurogenin1 effectively reprograms cultured chick retinal pigment epithelial cells to differentiate toward photoreceptors.The Journal of comparative neurology · 2010Article
- Using neurogenin to reprogram chick RPE to produce photoreceptor-like neurons.Investigative ophthalmology & visual science · 2010Article
- Pro-photoreceptor activity of chick neurogenin1.Investigative ophthalmology & visual science · 2009Article
- Liquiritin potentiate neurite outgrowth induced by nerve growth factor in PC12 cells.Cytotechnology · 2009Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
The transcriptional regulatory network governing the establishment of retinal neuron diversity is not well delineated. We report experimental results suggesting proneural gene neurogenin3 (ngn3) participating in this regulatory network. Retinal expression of chick ngn3 was confined to early neurogenesis. Overexpression of ngn3 in chick retina reduced cell proliferation and expanded the population of ganglion cells into the territory normally occupied by amacrine cells. Ngn3 overexpression altered the expression of a number of regulatory genes, including ash1, ath3, ath5, chx10, neuroD, ngn1, ngn2, and NSCL1. Early gene ngn1 was induced, but ash1, ngn2, ath3, and chx10, whose expressions persist through later phases of neurogenesis, were down-regulated. Expression of ath5 was up-regulated at the locale corresponding to young ganglion cells, but was down-regulated at the locale corresponding to progenitor cells. These results suggest that ngn3 regulates retinal neurogenesis by inducing regulatory genes for early-born neurons and repressing those for later-born cells.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.