ArticlePeptides2009
Administration of IL-1beta to the 4th ventricle causes anorexia that is blocked by agouti-related peptide and that coincides with activation of tyrosine-hydroxylase neurons in the nucleus of the solitary tract.
Article in Peptides, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
16 citing papers in PubMed, 39 citations in OpenAlex.
- The effect of conjugated linoleic acid supplementation on the nutritional status of COPD patients.International journal of chronic obstructive pulmonary disease · 2016Trial
- Progress in the study of nutritional status and selenium in dialysis patients.Annals of medicine · 2023Review
- Viral Infection Drives the Regulation of Feeding Behavior Related Genes inInternational journal of molecular sciences · 2021Article
- NF-κB signaling in tanycytes mediates inflammation-induced anorexia.Molecular metabolism · 2020Article
- Mimecan, a Hormone Abundantly Expressed in Adipose Tissue, Reduced Food Intake Independently of Leptin Signaling.EBioMedicine · 2015Article
- Participation of the central melanocortin system in metabolic regulation and energy homeostasis.Cellular and molecular life sciences : CMLS · 2014Review
- Article
- A patient with CKD and poor nutritional status.Clinical journal of the American Society of Nephrology : CJASN · 2013Article
- Optimal nutrition in hemodialysis patients.Advances in chronic kidney disease · 2013Review
- The use of ghrelin and ghrelin receptor agonists as a treatment for animal models of disease: efficacy and mechanism.Current pharmaceutical design · 2012Review
- GABAergic signaling by AgRP neurons prevents anorexia via a melanocortin-independent mechanism.European journal of pharmacology · 2011Review
- Neuropeptides in the pathophysiology and treatment of cachexia.Current opinion in supportive and palliative care · 2010Review
- Changes in melanocortin expression and inflammatory pathways in fetal offspring of nonhuman primates fed a high-fat diet.Endocrinology · 2010Article
- Update on melanocortin interventions for cachexia: progress toward clinical application.Nutrition (Burbank, Los Angeles County, Calif.) · 2010Review
- Animal models of anorexia and cachexia.Expert opinion on drug discovery · 2009Article
- Neurobiology of inflammation-associated anorexia.Frontiers in neuroscience · 2009Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
Inflammation-associated cachexia is associated with multiple chronic diseases and involves activation of appetite regulating centers in the arcuate nucleus of the hypothalamus (ARH). The nucleus of the solitary tract (NTS) in the brainstem has also been implicated as an important nucleus involved in appetite regulation. We set out to determine whether the NTS may be involved in inflammation-associated anorexia by injecting IL-1 beta into the 4th ventricle and assessing food intake and NTS neuronal activation. Injection of IL-1 beta produced a decrease in food intake at 3 and 12h after injection which was ameliorated at the 12h time point by a sub-threshold dose of agouti-related peptide (AgRP). Investigation into neuron types in the NTS revealed that IL-1 beta injection was associated with an increase in c-Fos activity in NTS neurons expressing tyrosine hydroxylase (TH). Additionally, injection of IL-1 beta into the 4th ventricle did not produce c-Fos activation of neurons expressing pro-opiomelanocortin (POMC) in the ARH, cells known to be involved in producing anorexia in response to systemic inflammation. Double-label in situ hybridization revealed that TH neurons did not express IL-1 receptor I (IL1-RI) transcript, demonstrating that c-Fos activation of TH neurons in this setting was not via direct stimulation of IL-1 beta on TH neurons themselves. We conclude that IL-1 beta injection into the 4th ventricle produces anorexia and is accompanied by an increase in activation in TH neurons in the NTS. This provides evidence that the brainstem may be an important mediator of anorexia in the setting of inflammation.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.