ReviewNeuroscience and biobehavioral reviews2009
A developmental neurobiological model of motivated behavior: anatomy, connectivity and ontogeny of the triadic nodes.
Review in Neuroscience and biobehavioral reviews, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 178 papers, 6 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
178 citing papers in PubMed, 6 syntheses or guidelines pooled it.
- Grey matter structural alterations in anxiety disorders: a voxel-based meta-analysis.Brain imaging and behavior · 2024Pooled it
- The brain in social context: A systematic review of substance use and social processing from adolescence to young adulthood.Developmental cognitive neuroscience · 2022Pooled it
- Spatial migration of human reward processing with functional development: Evidence from quantitative meta-analyses.Human brain mapping · 2020Pooled it
- Neural networks involved in adolescent reward processing: An activation likelihood estimation meta-analysis of functional neuroimaging studies.NeuroImage · 2015Pooled it
- The nature of individual differences in inhibited temperament and risk for psychiatric disease: A review and meta-analysis.Progress in neurobiology · 2015Pooled it
- A systematic review of fMRI reward paradigms used in studies of adolescents vs. adults: the impact of task design and implications for understanding neurodevelopment.Neuroscience and biobehavioral reviews · 2013Pooled it
- Oxytocin and vasopressin modulate risk-taking.Physiology & behavior · 2015Trial
- Incentive processing in Congenital Adrenal Hyperplasia (CAH): a reward-based antisaccade study.Psychoneuroendocrinology · 2013Trial
- Two sides of the same coin: learning via positive and negative reinforcers in the human striatum.Developmental cognitive neuroscience · 2011Trial
- Enhanced right amygdala activity in adolescents during encoding of positively valenced pictures.Developmental cognitive neuroscience · 2011Trial
- Sleep regulates drug seeking and relapse - a perspective.Molecular psychiatry · 2026Review
- Structural and Functional Brain Changes in Children and Adolescents With Obesity.Obesity reviews : an official journal of the International Association for the Study of Obesity · 2025Review
- The (un-)Social Brain in Isolation.Physiological research · 2025Review
- Behavioral and neural dysfunctions in reward-related cognitive control among adolescents with major depressive disorder.Psychological medicine · 2025Article
- Family History of Substance Use and Stressful Life Events Impact Adolescent Maturation of Cerebral White Matter.Addiction biology · 2025Article
- Neural Signatures of Cognitive Control Predict Future Adolescent Substance Use Onset and Frequency.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2025Article
- Modulation of intracortical circuits in primary motor cortex during automatic action tendencies.Brain structure & function · 2024Article
- Gender differences in borderline personality disorder: a narrative review.Frontiers in psychiatry · 2024Review
- Comparing self-regulation strategies among adult learners from Poland, Serbia, Slovakia, and the Czech Republic.Frontiers in psychology · 2024Article
- Age-dependent alterations in the coordinated development of subcortical regions in adolescents with social anxiety disorder.European child & adolescent psychiatry · 2024Article
118 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
Abstract
Adolescence is the transition period that prepares individuals for fulfilling their role as adults. Most conspicuous in this transition period is the peak level of risk-taking behaviors that characterize adolescent motivated behavior. Significant neural remodeling contributes to this change. This review focuses on the functional neuroanatomy underlying motivated behavior, and how ontogenic changes can explain the typical behavioral patterns in adolescence. To help model these changes and provide testable hypotheses, a neural systems-based theory is presented. In short, the Triadic Model proposes that motivated behavior is governed by a carefully orchestrated articulation among three systems, approach, avoidance and regulatory. These three systems map to distinct, but overlapping, neural circuits, whose representatives are the striatum, the amygdala and the medial prefrontal cortex. Each of these system-representatives will be described from a functional anatomy perspective that includes a review of their connectivity and what is known of their ontogenic changes.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.