ArticleBioorganic & medicinal chemistry2009
From nature to the laboratory and into the clinic.
Article in Bioorganic & medicinal chemistry, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed.
- Enantioselective C-H functionalization: logic and applications in the total synthesis of natural products.Chemical science · 2026Review
- Inorganic Nanoparticles: Tools to Emphasize the Janus Face of Amphotericin B.Antibiotics (Basel, Switzerland) · 2023Review
- TheMolecules (Basel, Switzerland) · 2023Article
- Naturally Occurring Organohalogen Compounds-A Comprehensive Review.Progress in the chemistry of organic natural products · 2023Review
- A simple protocol for determination of enantiopurity of amines using BINOL derivatives as chiral solvating agentsRSC advances · 2022Article
- Natural Products in the "Marketplace": Interfacing Synthesis and Biology.Journal of the American Chemical Society · 2019Review
- Synthetic Access to the Mandelalide Family of Macrolides: Development of an Anion Relay Chemistry Strategy.The Journal of organic chemistry · 2018Article
- Strategies for the Optimization of Natural Leads to Anticancer Drugs or Drug Candidates.Medicinal research reviews · 2016Review
- Spirotetronate polyketides as leads in drug discovery.Journal of natural products · 2015Review
- Total synthesis of jiadifenolide.Angewandte Chemie (International ed. in English) · 2014Article
- Search for highly efficient, stereoselective, and practical synthesis of complex organic compounds of medicinal importance as exemplified by the synthesis of the C21-C37 fragment of amphotericin B.Chemistry (Weinheim an der Bergstrasse, Germany) · 2013Article
- Synthesis and biological evaluation of new paclitaxel analogs and discovery of potent antitumor agents.Organic & biomolecular chemistry · 2013Article
- The lipophilic bullet hits the targets: medicinal chemistry of adamantane derivatives.Chemical reviews · 2013Review
- Constructing molecular complexity and diversity: total synthesis of natural products of biological and medicinal importance.Chemical Society reviews · 2012Review
- Bio-inspired synthesis and biological evaluation of a colchicine-related compound library.Bioorganic & medicinal chemistry letters · 2012Article
- Design, synthesis, and biological evaluation of a biyouyanagin compound library.Proceedings of the National Academy of Sciences of the United States of America · 2011Article
- Total synthesis and configurational assignment of chondramide A.Chemistry (Weinheim an der Bergstrasse, Germany) · 2010Article
- Current status and contemporary approaches to the discovery of antitumor agents from higher plants.Biotechnology advancesReview
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
Abstract
Natural products possess a broad diversity of structure and function, and they provide inspiration for chemistry, biology, and medicine. In this review article, we highlight and place in context our laboratory's total syntheses of, and related studies on, complex secondary metabolites that were clinically important drugs, or have since been developed into useful medicines, namely amphotericin B (1), calicheamicin gamma(1)(I) (2), rapamycin (3), Taxol (4), the epothilones [e.g., epothilones A (5) and B (6)], and vancomycin (7). We also briefly highlight our research with other selected inspirational natural products possessing interesting biological activities [i.e., dynemicin A (8), uncialamycin (9), eleutherobin (10), sarcodictyin A (11), azaspiracid-1 (12), thiostrepton (13), abyssomicin C (14), platensimycin (15), platencin (16), and palmerolide A (17)].
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.