ReviewThe Journal of surgical research2009
The role of vascular endothelial growth factor in wound healing.
Review in The Journal of surgical research, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 482 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
482 citing papers in PubMed, 3 syntheses or guidelines pooled it, 1,171 citations in OpenAlex.
- Quercetin as a therapeutic agent for skin problems: a systematic review and meta-analysis on antioxidant effects, oxidative stress, inflammation, wound healing, hyperpigmentation, aging, and skin cancer.Naunyn-Schmiedeberg's archives of pharmacology · 2025Pooled it
- Efficacy of anti-vascular endothelial growth factor and mitomycin C on wound healing after trabeculectomy in glaucoma patients: A meta-analysis.International wound journal · 2024Pooled it
- Cytokines and Venous Leg Ulcer Healing-A Systematic Review.International journal of molecular sciences · 2022Pooled it
- Effect of self-activating phthalocyanine gel on palatal donor site healing, inflammatory biomarkers, somatosensory and patient-centered outcomes: a randomized split-mouth clinical trial.Clinical oral investigations · 2026Trial
- Low-level laser therapy on soft tissue healing after implantation: a randomized controlled trial.BMC oral health · 2024Trial
- A purified reconstituted bilayer matrix shows improved outcomes in treatment of non-healing diabetic foot ulcers when compared to the standard of care: Final results and analysis of a prospective, randomized, controlled, multi-centre clinical trial.International wound journal · 2024Trial
- Efficacy of a novel microneedle patch for rejuvenation of the nasolabial fold.Skin research and technology : official journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging (ISSI) · 2022Trial
- PVA/chitosan-based hydrogels integrated with tilapia skin-derived collagen and Urtica dioica offers a promising approach for effective burn wound healing via transcriptional modulation of bFgf, Mmp2, Jak/Stat3, and α-Sma signaling pathway.Naunyn-Schmiedeberg's archives of pharmacology · 2026Article
- Infection, Angiogenesis, and Host-Microbe Interactions: Does VEGF Signaling Affect Wound Healing After Anal Fistula Surgery?Digestive diseases and sciences · 2026Article
- Cabozantinib-associated therapy-refractory lower-leg ulcers in metastatic renal cell carcinoma.JAAD case reports · 2026Article
- Mechanistic Evaluation of Luteolin in Wound Healing of Diabetic Foot Ulcer via Nrf2 Signaling.Phytotherapy research : PTR · 2026Article
- CNP-miR146a Promotes NRF2-Related Ferroptosis-Protective Myeloid Programs and Immune-Vascular Regeneration in Diabetic Wounds.Pharmaceutics · 2026Article
- Angiogenic Doping: Plausible Yet Difficult to Detect.Sports medicine (Auckland, N.Z.) · 2026Review
- Lysophosphatidic acid promotes cutaneous wound healing through vascular maturation and fibroblast activation in a murine model.Inflammation and regeneration · 2026Article
- Glycine-Functionalized Polycaprolactone Electrospun Nanofibers as Bioactive Scaffolds for Skin Repair.Polymers · 2026Article
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- The effects of platelet rich plasma and zinc oxide nanoparticle on skin wound healing in dogs.Scientific reports · 2026Article
- AirborneAdvanced healthcare materials · 2026Article
- Human Amniotic Membrane Dressing as a Non-Surgical Alternative for Extensive Chronic Ulcers: A Comparative Case Study.International journal of molecular sciences · 2026Article
422 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 5 institutions in 1 country.
Funding
Abstract
backgroundA chronic wound is tissue with an impaired ability to heal. This is often a consequence of one of the following etiologies: diabetes, venous reflux, arterial insufficiency sickle cell disease, steroids, and/or pressure. Healing requires granulation tissue depending on epithelialization and angiogenesis. Currently no growth factor is available to treat patients with impaired healing that stimulates both epithelialization and angiogenesis. The objective is to review is the multiple mechanisms of vascular endothelial growth factor (VEGF) in wound healing. MATERIALS AND
methodsThe authors reviewed the literature on the structure and function of VEGF, including its use for therapeutic angiogenesis. Particular attention is given to the specific role of VEGF in the angiogenesis cascade, its relationship to other growth factors and cells in a healing wound.
resultsVEGF is released by a variety of cells and stimulates multiple components of the angiogenic cascade. It is up-regulated during the early days of healing, when capillary growth is maximal. Studies have shown the efficacy of VEGF in peripheral and cardiac ischemic vascular disease with minimal adverse effects. Experimental data supports the hypothesis that VEGF stimulates epithelialization and collagen deposition in a wound.
conclusionVEGF stimulates wound healing through angiogenesis, but likely promotes collagen deposition and epithelialization as well. Further study of the molecule by utilizing the protein itself, or novel forms of delivery such as gene therapy, will increase its therapeutic possibilities to accelerate closure of a chronic wound.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.