ReviewBrain research reviews2009
Neurogliogenesis in the mature olfactory system: a possible protective role against infection and toxic dust.
Review in Brain research reviews, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
15 citing papers in PubMed, 38 citations in OpenAlex.
- Neural stem cells in adult neurogenesis and their therapeutic applications in neurodegenerative disorders: a concise review.Frontiers in molecular medicine · 2025Review
- COVID-19 causes neuronal degeneration and reduces neurogenesis in human hippocampus.Apoptosis : an international journal on programmed cell death · 2022Article
- FeInternational journal of molecular sciences · 2022Article
- COVID-19 and Parkinson's disease: Defects in neurogenesis as the potential cause of olfactory system impairments and anosmia.Journal of chemical neuroanatomy · 2021Review
- Validating a Genomic Convergence and Network Analysis Approach Using Association Analysis of Identified Candidate Genes in Alzheimer's Disease.Frontiers in genetics · 2021Article
- Is anosmia the price to pay in an immune-induced scorched-earth policy against COVID-19?Medical hypotheses · 2020Article
- SARS-CoV-2 Dissemination Through Peripheral Nerves Explains Multiple Organ Injury.Frontiers in cellular neuroscience · 2020Article
- The Olfactory Bulb: An Immunosensory Effector Organ during Neurotropic Viral Infections.ACS chemical neuroscience · 2016Review
- Canonical Wnt Signaling Drives Tumor-Like Lesions from Sox2-Positive Precursors of the Murine Olfactory Epithelium.PloS one · 2016Article
- Oxidative Stress and Adult Neurogenesis.Stem cell reviews and reports · 2015Review
- Occurrence of new neurons in the piriform cortex.Frontiers in neuroanatomy · 2014Review
- Inflammation and α-synuclein's prion-like behavior in Parkinson's disease--is there a link?Molecular neurobiology · 2013Review
- Hippocampal asymmetry: differences in structures and functions.Neurochemical research · 2013Review
- Canonical Wnt signaling promotes the proliferation and neurogenesis of peripheral olfactory stem cells during postnatal development and adult regeneration.Journal of cell science · 2011Article
- Neuroinflammation resulting from covert brain invasion by common viruses - a potential role in local and global neurodegeneration.Medical hypotheses · 2010Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 3 institutions in 4 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The outpost position of the olfactory bulb (OB) between the direct inputs from sensory neurons of the nasal epithelium and other parts of the brain suggests its highest vulnerability among all brain structures to penetration of exogenous agents. A number of neurotropic viruses have been found to invade the brain through the OB. There is growing evidence that microscopic particles of toxic dusts can propagate from the nasal epithelium to the OB and further into the brain. These harmful agents impair cellular elements of the brain. Apparently, cells in the OB are the most affected, as they are the first to encounter viral infections and toxic particles. It is well known that neuronal and glial progenitors are continuously generated from neuronal stem cells in the subventricular zone of the adult brain and then migrate predominantly into the OB. Therefore, it is feasible to suggest that substitution of injured or dead cells in the OB by new-born neurons, differentiating from progenitors, plays a role in protecting the OB neuronal microcircuits from destruction. Furthermore, some cytokines and chemokines released in response to infection and/or intoxication can modulate different stages of neurogenesis (proliferation, migration, and differentiation). We hypothesize that continuous neurogenesis in the olfactory system throughout adulthood evolved as a protective mechanism to prevent impairment of the most ancient but vitally important sensory system. In addition, differentiation of a substantial portion of progenitors to glial cells, including macrophages and microglia, may create an additional barrier to exogenous agents on their way deep to the brain.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.