ArticleJournal of the American Dietetic Association2008
Nutrient intake and immune function of elderly subjects.
Article in Journal of the American Dietetic Association, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
7 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Contribution of Biological Age-Predictive Biomarkers to Nutrition Research: A Systematic Review of the Current Evidence and Implications for Future Research and Clinical Practice.Advances in nutrition (Bethesda, Md.) · 2022Pooled it
- Evidence for sex-specific intramuscular changes associated to physical weakness in adults older than 75 years.Biology of sex differences · 2023Article
- Caregivers' male gender is associated with poor nutrient intake in AD families (NuAD-trial).The journal of nutrition, health & aging · 2014Article
- Management of breast cancer patients with chemotherapy-induced neutropenia or febrile neutropenia.Breast care (Basel, Switzerland) · 2014Review
- Immunological and nutritional factors in elderly people in low-level care and their association with mortality.Immunity & ageing : I & A · 2013Article
- The role of selenium in inflammation and immunity: from molecular mechanisms to therapeutic opportunities.Antioxidants & redox signaling · 2012Review
- Ten-year trends in vitamin intake in free-living healthy elderly people: the risk of subclinical malnutrition.The journal of nutrition, health & aging · 2011Article
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
objectiveFood intake, aging, and immune function share complex influences. Therefore, the purpose of this study was to examine relationships between nutrient intakes from food and dietary supplements and a biomarker of immune function.
designData were collected from participants in a cross-sectional study as well as baseline data from a longitudinal study (n=89). Subjects completed 24-hour food recalls, including supplement intake. Polyclonal mitogen phytohemmagluttin (PHA) was the immune function stimulator used. Height and weight were used to calculate body mass index. STATISTICAL ANALYSES PERFORMED: Descriptive, bivariate correlation, Spearman's rho for nonparametric data, t tests, and stepwise regression with nutrient intakes as independent variables and T-cell proliferation as dependent variables.
resultsSignificant positive correlations (P< or =0.05) were found between PHA-induced proliferation and intake of docosahexaenoic acid (DHA), eicosahexaenoic acid (EPA), sodium, and selenium, although intakes of DHA plus EPA were inadequate when compared to recommended intakes. A significant negative correlation with total vitamin A, with many vitamin A levels being above the upper limit of safety. Regression analyses found these nutrients to be variables significant in explaining the variance in PHA (P=0.005).
conclusionsSelenium, sodium, DHA, EPA, and vitamin A intake from diet and supplements were associated with PHA-induced proliferative responses. Clients may be counseled to have adequate selenium, EPA, DHA intake, and vitamin A, but avoid excess vitamin A.
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