ArticleTuberculosis (Edinburgh, Scotland)2009
Does the lipR gene of tubercle bacilli have a role in tuberculosis transmission and pathogenesis?
Article in Tuberculosis (Edinburgh, Scotland), 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
5 citing papers in PubMed, 12 citations in OpenAlex.
- Uncovering the genomic landscape of Mycobacterium bovis in Wales.Scientific reports · 2026Article
- Roles of Lipolytic enzymes inFrontiers in microbiology · 2024Review
- Disease phenotypic and geospatial features vary across genetic lineages for Tuberculosis within Arkansas, 2010-2020.PLOS global public health · 2023Article
- Sequence Analysis of lip R: A Good Method for Molecular Epidemiology of Clinical Isolates of Mycobacterium tuberculosis.Current microbiology · 2015Article
- Identification of factors for tuberculosis transmission via an integrated multidisciplinary approach.Tuberculosis (Edinburgh, Scotland) · 2011Article
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Authors and funding
9 authors at 2 institutions in 1 country.
Funding
Abstract
Mycobacterium tuberculosis lipases, a diverse class of enzymes involved in lipid metabolism, may have an important role in tuberculosis (TB) pathogenesis. We explored the association of large sequence polymorphism (LSP) in one of the M. tuberculosis lipase-encoding genes, lipR (Rv3084), with patient characteristics using a population-based sample of clinical isolates to elucidate the potential role of lipR in TB pathogenesis. LSP in lipR was found in 104 (15.6%) of 665 isolates, of which 96% belonged to principal genetic group 3. When linkage by molecular type and epidemiologic evidence were compared, molecularly clustered cases infected with a lipR LSP isolate were more often epidemiologically linked than clustered cases infected with a lipR wild-type isolate. Further epidemiologic and functional studies are necessary to determine if the association between this lipR LSP and recent transmission we identified in this population reflects a functional role of lipR in TB transmission and pathogenesis or other unidentified mechanisms.
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