ArticleJournal of neuroimmunology2009
Expression and regulation of antiviral protein APOBEC3G in human neuronal cells.
Article in Journal of neuroimmunology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed, 34 citations in OpenAlex.
- When R-Loops Go Awry: Genome Instability and Neurological Diseases.The European journal of neuroscience · 2026Review
- Replicative fitness and pathogenicity of primate lentiviruses in lymphoid tissue, primary human and chimpanzee cells: relation to possible jumps to humans.EBioMedicine · 2024Article
- Muons, mutations, and planetary shielding.Frontiers in astronomy and space sciences · 2022Article
- Mutagenic Activity of AID/APOBEC Deaminases in Antiviral Defense and Carcinogenesis.Molecular biology · 2022Article
- Insights into the Gene Expression Profiles of Active and Restricted Red/Green-HIVJournal of virology · 2020Article
- SupT1 Cell Infusion as a Possible Cell-Based Therapy for HIV: Results from a Pilot Study in Hu-PBMC BRGS Mice.Vaccines · 2016Article
- A computational analysis of the structural determinants of APOBEC3's catalytic activity and vulnerability to HIV-1 Vif.Virology · 2014Article
- Toll-like receptor 3 signaling inhibits simian immunodeficiency virus replication in macrophages from rhesus macaques.Antiviral research · 2014Article
- Multiple APOBEC3 restriction factors for HIV-1 and one Vif to rule them all.Journal of molecular biology · 2014Review
- Changes in neural network homeostasis trigger neuropsychiatric symptoms.The Journal of clinical investigation · 2014Article
- Is a pacific coexistence between virus and host the unexploited path that may lead to an HIV functional cure?Viruses · 2013Article
- Genetic variants in the host restriction factor APOBEC3G are associated with HIV-1-related disease progression and central nervous system impairment in children.Journal of acquired immune deficiency syndromes (1999) · 2013Article
- Emerging molecular targets for brain repair after stroke.Stroke research and treatment · 2013Article
- IFN-α and lipopolysaccharide upregulate APOBEC3 mRNA through different signaling pathways.Journal of immunology (Baltimore, Md. : 1950) · 2012Article
- Genetic knockouts suggest a critical role for HIV co-receptors in models of HIV gp120-induced brain injury.Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology · 2012Review
- Non-coding RNA networks underlying cognitive disorders across the lifespan.Trends in molecular medicine · 2011Review
- NFAT and IRF proteins regulate transcription of the anti-HIV gene, APOBEC3G.The Journal of biological chemistry · 2011Article
- Association of TRIM22 with the type 1 interferon response and viral control during primary HIV-1 infection.Journal of virology · 2011Article
- Interferon lambda inhibits herpes simplex virus type I infection of human astrocytes and neurons.Glia · 2011Article
- The emerging role of epigenetics in stroke: II. RNA regulatory circuitry.Archives of neurology · 2010Review
Corrections and comments
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Authors and funding
9 authors at 3 institutions in 1 country.
Funding
Abstract
Apolipoprotein B mRNA-editing enzyme, catalytic polypeptide-like 3G (APOBEC3G) has recently been identified as a potent antiviral protein. Here, we examined the expression and regulation of APOBEC3G in human brain tissues and the cells of central nervous system (CNS). Similar to the immune cells, human brain tissue and the CNS cells expressed APOBEC3G at both mRNA and protein levels. The expression of APOBEC3G could be up-regulated in human neuronal cells (NT2-N) and astrocytes (U87-MG) by interferons (IFN-alpha, beta and gamma), interleukin-1 (IL-1), and tumor necrosis factor. Other cytokines (IL-4, IL-6 and transforming growth factor beta1) and CC-chemokines (CCL3, 4 and 5), however, had little impact on the expression of APOBEC3G. In addition, pseudotyped HIV-1 infection and cytokine/chemokine-enriched supernatants from lipopolysaccharide-stimulated macrophage cultures induced APOBEC3G expression in NT2-N cells. APOBEC3G expressed in the neuronal cells and astrocytes was biologically functional, as the suppression of APOBEC3G expression by the specific siRNA led to increase of pseudotyped HIV-1 replication in these cells. These findings provide direct and compelling evidence that there is intracellular expression and regulation of functional APOBEC3G in the neuronal cells, which may be one of innate defense mechanisms involved in the neuronal protection in the CNS.
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