ArticlePlacenta2009
Altered global gene expression in first trimester placentas of women destined to develop preeclampsia.
Article in Placenta, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 124 papers, 2 of them syntheses that pooled it.
What it found
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Who cites it
124 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Current approaches and developments in transcript profiling of the human placenta.Human reproduction update · 2020Pooled it
- Differentially expressed genes in the pre-eclamptic placenta: a systematic review and meta-analysis.PloS one · 2013Pooled it
- Trial
- Genome-wide transcriptome directed pathway analysis of maternal pre-eclampsia susceptibility genes.PloS one · 2015Trial
- Multi-Omics Reveals Early Pregnancy Placental Dysfunction Associated With Preterm and Term Preeclampsia.MedComm · 2026Article
- Aberrant Uteroplacental and Vascular Signaling and Remodeling by Matrix Metalloproteinases in Pregnancy-Related Hypertension and Preeclampsia.Biomolecules · 2026Review
- The multifactorial role of HDAC9 at the maternal-fetal interface in the pathogenesis of preeclampsia.Clinical science (London, England : 1979) · 2025Review
- The endothelin-1 system among high-risk pregnant women with obstructive sleep apnea.Journal of sleep research · 2025Article
- Article
- Antagonisation of Prokineticin Receptor-2 Attenuates Preeclampsia Symptoms.Journal of cellular and molecular medicine · 2025Article
- Trophoblast Side-Population Markers are Dysregulated in Preeclampsia and Fetal Growth Restriction.Stem cell reviews and reports · 2024Article
- Placental growth factor mediates pathological uterine angiogenesis by activating the NFAT5-SGK1 signaling axis in the endometrium: implications for preeclampsia development.Biological research · 2024Article
- METTL3-mediated lncRNA HOXD-AS1 stability regulates inflammation, and the migration and invasion of trophoblast cells via the miR-135a/ β-TRCP axis.Non-coding RNA research · 2024Article
- Expression and significance of cathepsin C and cathepsin D during pregnancy and Preeclampsia.Reproductive biology and endocrinology : RB&E · 2023Article
- Cyclic processes in the uterine tubes, endometrium, myometrium, and cervix: pathways and perturbations.Molecular human reproduction · 2023Review
- The human placenta: new perspectives on its formation and function during early pregnancy.Proceedings. Biological sciences · 2023Article
- Early Mid-pregnancy Blood-Based Proteins as Possible Biomarkers of Increased Infant Birth Size in Sex-Stratified Analyses.Reproductive sciences (Thousand Oaks, Calif.) · 2023Article
- Pre-eclampsia.Nature reviews. Disease primers · 2023Review
- Energy metabolism and maternal-fetal tolerance working in decidualization.Frontiers in immunology · 2023Review
- Endometrial stromal cell miR-19b-3p release is reduced during decidualization implying a role in decidual-trophoblast cross-talk.Frontiers in endocrinology · 2023Article
64 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
backgroundPreeclampsia is a pregnancy-specific disorder that remains a leading cause of maternal, fetal and neonatal morbidity and mortality, and is associated with risk for future cardiovascular disease. There are no reliable predictors, specific preventative measures or treatments other than delivery. A widely held view is that the antecedents of preeclampsia lie with impaired placentation in early pregnancy. Accordingly, we hypothesized dysregulation of global gene expression in first trimester placentas of women who later manifested preeclampsia.
methodsSurplus chorionic villus sampling (CVS) tissues were collected at 10-12 weeks gestation in 160 patients with singleton fetuses. Four patients developed preeclampsia, and their banked CVS specimens were matched to 8 control samples from patients with unaffected pregnancies. Affymetrix HG-U133 Plus 2.0 GeneChips were utilized for microarray analysis. Naïve Bayes prediction modeling and pathway analysis were conducted. qRT-PCR examined three of the dysregulated genes.
resultsThirty-six differentially expressed genes were identified in the preeclampsia placentas. qRT-PCR verified the microarray analysis. Thirty-one genes were down-regulated. Many were related to inflammation/immunoregulation and cell motility. Decidual gene dysregulation was prominent. No evidence was found for alterations in hypoxia and oxidative stress regulated genes.
conclusionsTo our knowledge, this is the first study to show dysregulation of gene expression in the early placentas of women approximately 6 months before developing preeclampsia, thereby reinforcing a placental origin of the disorder. We hypothesize that placentation in preeclampsia is compromised in the first trimester by maternal and fetal immune dysregulation, abnormal decidualization, or both, thereby impairing trophoblast invasion. Several of the genes provide potential targets for the development of clinical biomarkers in maternal blood during the first trimester. Supplementary materials are available for this article via the publisher's online edition.
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