Why did the NHE inhibitor clinical trials fail?

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

Who cites it

18 citing papers in PubMed.

1. Regulation of Na/Ca exchange by cytoplasmic protons modifies intracellular calcium dynamics and the cardiac response to ischemia.Proceedings of the National Academy of Sciences of the United States of America · 2025
   Article
2. Mechanisms of postischemic cardiac death and protection following myocardial injury.The Journal of clinical investigation · 2025
   Review
3. Mitochondrial calcium and reactive oxygen species in cardiovascular disease.Cardiovascular research · 2023
   Review
4. NaPharmaceuticals (Basel, Switzerland) · 2022
   Review
5. Nutrient scavenging in cancer.Nature reviews. Cancer · 2018
   Review
6. Is there a causal link between intracellular Na elevation and metabolic remodelling in cardiac hypertrophy?Biochemical Society transactions · 2018
   Review
7. Lung Circulation.Comprehensive Physiology · 2016
   Review
8. The RSK Inhibitor BIX02565 Limits Cardiac Ischemia/Reperfusion Injury.Journal of cardiovascular pharmacology and therapeutics · 2016
   Article
9. Vascular remodeling in pulmonary hypertension.Journal of molecular medicine (Berlin, Germany) · 2013
   Review
10. NHE isoform switching and KChIP2 upregulation in aging porcine atria.PloS one · 2013
    Article
11. Mitochondrial NHE1: a newly identified target to prevent heart disease.Frontiers in physiology · 2013
    Article
12. The role of Na+/H+ exchanger in Ca2+ overload and ischemic myocardial damage in hearts from type 2 diabetic db/db mice.Cardiovascular diabetology · 2012
    Article
13. What makes the mitochondria a killer? Can we condition them to be less destructive?Biochimica et biophysica acta · 2011
    Review
14. Activation of microglia depends on Na+/H+ exchange-mediated H+ homeostasis.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2010
    Article
15. Riluzole protects against cardiac ischaemia and reperfusion damage via block of the persistent sodium current.British journal of pharmacology · 2010
    Article
16. Targeting calcium transport in ischaemic heart disease.Cardiovascular research · 2009
    Review
17. Regulation of intracellular and mitochondrial sodium in health and disease.Circulation research · 2009
    Review
18. The role of comorbidities in cardioprotection.Journal of cardiovascular pharmacology and therapeutics
    Review

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

Authors and funding

2 authors.

Funding

Abstract

PubMed holds no abstract for this paper.

Indexed as