ReviewBiochemical pharmacology2009
Conserved genomic structure of the Cyp1a1 and Cyp1a2 loci and their dioxin responsive elements cluster.
Review in Biochemical pharmacology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
14 citing papers in PubMed, 1 synthesis or guideline pooled it, 32 citations in OpenAlex.
- Sequence variants at CYP1A1-CYP1A2 and AHR associate with coffee consumption.Human molecular genetics · 2011Pooled it
- Habitual coffee consumption poorly correlates with sleep quality and daytime sleepiness: A cross-sectional study.PloS one · 2026Article
- The role of transcription factors in shaping regulatory T cell identity.Nature reviews. Immunology · 2023Review
- Evidence for crosstalk between the aryl hydrocarbon receptor and the translocator protein in mouse lung epithelial cells.Experimental cell research · 2023Article
- Evolution of Hominin Detoxification: Neanderthal and Modern Human Ah Receptor Respond Similarly to TCDD.Molecular biology and evolution · 2021Article
- Polycyclic Aromatic Hydrocarbon-induced Pulmonary Carcinogenesis in Cytochrome P450 (CYP)1A1- and 1A2-Null Mice: Roles of CYP1A1 and CYP1A2.Toxicological sciences : an official journal of the Society of Toxicology · 2020Article
- Genome-Wide Transcriptional Analysis Reveals Novel AhR Targets That Regulate Dendritic Cell Function during Influenza A Virus Infection.ImmunoHorizons · 2019Article
- Regulation of Human Cytochrome P4501A1 (hCYP1A1): A Plausible Target for Chemoprevention?BioMed research international · 2016Review
- Aryl hydrocarbon receptor-dependent apoptotic cell death induced by the flavonoid chrysin in human colorectal cancer cells.Cancer letters · 2016Article
- SIN3A, generally regarded as a transcriptional repressor, is required for induction of gene transcription by the aryl hydrocarbon receptor.The Journal of biological chemistry · 2014Article
- Functional analysis of the dioxin response elements (DREs) of the murine CYP1A1 gene promoter: beyond the core DRE sequence.International journal of molecular sciences · 2014Article
- Activation of aflatoxin B1 by expression of human CYP1A2 polymorphisms in Saccharomyces cerevisiae.Mutation research. Genetic toxicology and environmental mutagenesis · 2014Article
- Genome-wide RNAi high-throughput screen identifies proteins necessary for the AHR-dependent induction of CYP1A1 by 2,3,7,8-tetrachlorodibenzo-p-dioxin.Toxicological sciences : an official journal of the Society of Toxicology · 2013Article
- The role of the dioxin-responsive element cluster between the Cyp1a1 and Cyp1a2 loci in aryl hydrocarbon receptor biology.Proceedings of the National Academy of Sciences of the United States of America · 2009Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
A thorough DNA sequence analysis reveals that the mouse Cyp1a1 and Cyp1a2 loci are located with coding directions opposite to each other. The two genes are separated by approximately 13.9 kb of genomic DNA containing no open reading frames (mCyp1a1_1a2 junction). Within the mCyp1a1_1a2 junction, eight consensus dioxin responsive elements (DREs) are present and seven of the eight DREs located less than 1.4 kb upstream from the Cyp1a1 transcriptional start site. The genomic structure of mouse Cyp1a1 and Cyp1a2 loci is similar to that of human CYP1A1 and CYP1A2 loci. In the human CYP1A1 and CYP1A2 are also arranged in a head to head orientation and separated by a 23 kb genome junction (hCyp1A1_1A2). Comparative sequence analysis between these two genomic junctions demonstrated that the 1.4kb upstream region from the transcriptional start site of mouse Cyp1a1 was highly conserved with that of human CYP1A1. In contrast, there are no conserved DREs in the proximal upstream region of Cyp1a2. The "head to head" genomic structure and position of the DREs cluster region near the Cyp1a1 gene on Cyp1a1_1a2 were confirmed in cattle, dog and rat genome. These results suggest that the conservation of genomic structure of Cyp1a1 and Cyp1a2 genes, and the DREs cluster are important in mammalian biology.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.