ArticleMolecular and cellular neurosciences2009
Enhancement of the endosomal endocytic pathway increases quantal size.
Article in Molecular and cellular neurosciences, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed.
- Presynaptic quantal size enhancement counteracts post-tetanic release depression.The Journal of physiology · 2025Article
- Minibrain kinase and calcineurin coordinate activity-dependent bulk endocytosis through synaptojanin.The Journal of cell biology · 2021Article
- Article
- Article
- Focal Macropatch Recordings of Synaptic Currents from the Drosophila Larval Neuromuscular Junction.Journal of visualized experiments : JoVE · 2017Article
- FM1-43 Photoconversion and Electron Microscopy Analysis at theBio-protocol · 2017Article
- Electrophysiological analysis of synaptic transmission in Drosophila.Wiley interdisciplinary reviews. Developmental biology · 2017Review
- A Ca2+ channel differentially regulates Clathrin-mediated and activity-dependent bulk endocytosis.PLoS biology · 2017Article
- Complexin Mutants Reveal Partial Segregation between Recycling Pathways That Drive Evoked and Spontaneous Neurotransmission.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2017Article
- An Endocytic Scaffolding Protein together with Synapsin Regulates Synaptic Vesicle Clustering in the Drosophila Neuromuscular Junction.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2015Article
- Presynaptic active zones in invertebrates and vertebrates.EMBO reports · 2015Review
- Role of Bassoon and Piccolo in Assembly and Molecular Organization of the Active Zone.Frontiers in synaptic neuroscience · 2015Review
- Postsynaptic actin regulates active zone spacing and glutamate receptor apposition at the Drosophila neuromuscular junction.Molecular and cellular neurosciences · 2014Article
- AP180 couples protein retrieval to clathrin-mediated endocytosis of synaptic vesicles.Traffic (Copenhagen, Denmark) · 2014Article
- Complexin controls spontaneous and evoked neurotransmitter release by regulating the timing and properties of synaptotagmin activity.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2012Article
- Abnormal synaptic vesicle biogenesis in Drosophila synaptogyrin mutants.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2012Article
- A presynaptic endosomal trafficking pathway controls synaptic growth signaling.The Journal of cell biology · 2011Article
- Synapsin regulates vesicle organization and activity-dependent recycling at Drosophila motor boutons.Neuroscience · 2010Article
- Hermansky-Pudlak protein complexes, AP-3 and BLOC-1, differentially regulate presynaptic composition in the striatum and hippocampus.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2010Article
- Stimulation-induced formation of the reserve pool of vesicles in Drosophila motor boutons.Journal of neurophysiology · 2009Article
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2 authors.
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Abstract
We combined recordings of spontaneous quantal events with electron microscopy analysis of synaptic ultrastructure to demonstrate that the size of a neurosecretory quantum increases following an activation of the endosomal endocytic pathway. We reversibly activated the endosomal endocytic pathway in Drosophila motor boutons by application of high K+ solution. This treatment produced the formation of numerous cisternae, vacuoles and enlarged vesicles. Spontaneous quantal events recorded immediately after the cessation of high K+ application were significantly enlarged, and this increase in quantal size was reversed after a 10 minute resting period. Actin depolymerization produced by latrunculin B pretreatment inhibited both the formation of endosome-like structures and the increase in quantal size. Loading the preparations with the dye FM1-43 followed by photoconversion of the dye combined with electron microscopy analysis revealed that the observed cisternae are likely to be the product of both bulk membrane retrieval and vesicle fusion.
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