ArticleGene2009
Transcriptional regulation of the major zinc uptake protein hZip1 in prostate cancer cells.
Article in Gene, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
11 citing papers in PubMed.
- Cellular zinc metabolism and zinc signaling: from biological functions to diseases and therapeutic targets.Signal transduction and targeted therapy · 2024Review
- A comprehensive review of the role of zinc in normal prostate function and metabolism; and its implications in prostate cancer.Archives of biochemistry and biophysics · 2016Review
- Knockdown of Zinc Transporter ZIP5 by RNA Interference Inhibits Esophageal Cancer Growth In Vivo.Oncology research · 2016Article
- Coactivator SRC-2-dependent metabolic reprogramming mediates prostate cancer survival and metastasis.The Journal of clinical investigation · 2015Article
- Semenogelin I promotes prostate cancer cell growth via functioning as an androgen receptor coactivator and protecting against zinc cytotoxicity.American journal of cancer research · 2015Article
- A novel epigenetic CREB-miR-373 axis mediates ZIP4-induced pancreatic cancer growth.EMBO molecular medicine · 2013Article
- Article
- Assessing prostate cancer growth with citrate measured by intact tissue proton magnetic resonance spectroscopy.Prostate cancer and prostatic diseases · 2012Article
- Reversal of epigenetic silencing of AP-2alpha results in increased zinc uptake in DU-145 and LNCaP prostate cancer cells.Carcinogenesis · 2011Article
- Zinc bells rang in Jerusalem!Science signaling · 2010Article
- Ras responsive element binding protein-1 (RREB-1) down-regulates hZIP1 expression in prostate cancer cells.The Prostate · 2010Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
Abstract
hZip1 has been characterized as the major zinc uptake transporter regulating the accumulation of zinc in prostate cells. The mechanisms regulating expression of hZip1 have not been described. To explore the mechanisms of transcriptional regulation of the hZip1 gene, we determined the putative promoter sequence for hZip1 and identified the potential transcription start site within the predicted hZip1 promoter region. To further characterize the promoter region for basal hZip1 transcription, 3' and 5' deletion constructs and constructs with mutated binding sites for putative transcription factors were generated by PCR amplification and assessed for transcriptional activity with a luciferase reporter assay in PC-3 prostate cancer cells. The ability of the specific transcription factors to bind the hZip1 core promoter was confirmed by EMSA, GelSupershift and ChIP assays. Our experiments identified the core promoter region responsible for constitutive expression of hZip1 and demonstrated critical roles for SP1 and CREB1 in transcriptional regulation of the hZip1 gene in prostate cancer cells.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.