ArticleThe Biochemical journal1991
Interaction domains of neurofilament light chain and brain spectrin.
Article in The Biochemical journal, 1991. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed.
- Biomarkers for Transient Ischemic Attack: A Brief Perspective of Current Reports and Future Horizons.Journal of clinical medicine · 2022Review
- Transiently structured head domains control intermediate filament assembly.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- Neurofilaments and Neurofilament Proteins in Health and Disease.Cold Spring Harbor perspectives in biology · 2017Review
- Neurofilament subunits are integral components of synapses and modulate neurotransmission and behavior in vivo.Molecular psychiatry · 2015Article
- Inducing neurite outgrowth by mechanical cell stretch.BioResearch open access · 2013Article
- Neurofilament proteins in axonal regeneration and neurodegenerative diseases.Neural regeneration research · 2012Review
- Differential gene expression in motor and sensory Schwann cells in the rat femoral nerve.Journal of neuroscience research · 2012Article
- Article
- Neurofilaments form a highly stable stationary cytoskeleton after reaching a critical level in axons.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2009Article
- Review of the multiple aspects of neurofilament functions, and their possible contribution to neurodegeneration.Molecular neurobiology · 2008Review
- Neurofilament transport is dependent on actin and myosin.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2004Article
- Myosin Va binding to neurofilaments is essential for correct myosin Va distribution and transport and neurofilament density.The Journal of cell biology · 2002Article
- Sarcolemmal organization in skeletal muscle lacking desmin: evidence for cytokeratins associated with the membrane skeleton at costameres.Molecular biology of the cell · 2002Article
- Brain spectrin binding to the NMDA receptor is regulated by phosphorylation, calcium and calmodulin.The EMBO journal · 1998Article
- Splice variant-specific interaction of the NMDA receptor subunit NR1 with neuronal intermediate filaments.The Journal of neuroscience : the official journal of the Society for Neuroscience · 1998Article
- Biomarkers for acute diagnosis and management of stroke in neurointensive care units.Brain circulationReview
- Changes in the topography of a number of outer membrane proteins in cultured neurons in conditions of selective lesioning of different elements of the cytoskeleton with neurotoxins.Neuroscience and behavioral physiologyArticle
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We have previously demonstrated that brain spectrin binds to the low-molecular-mass subunit of neurofilaments (NF-L) [Frappier, Regnouf & Pradel (1987) Eur. J. Biochem. 169, 651-657]. In the present study, we seek to locate their respective binding domains. In the first part we demonstrate that brain spectrin binds to a 20 kDa domain of NF-L. This domain is part of the rod domain of neurofilaments and plays a role in the polymerization process. However, the polymerization state does not seem to have any influence on the interaction. In the second part, we provide evidence that NF-L binds to the beta-subunit of not only brain spectrin but also human and avian erythrocyte spectrins. The microtubule-associated protein, MAP2, which has also been shown to bind to microfilaments and neurofilaments, binds to the same domain of NF-L as spectrin does. Finally, among the tryptic peptides of brain spectrin, we show that some peptides of low molecular mass (35, 25, 20 and 18 kDa) co-sediment with either NF-L or F-actin.
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