ArticleCurrent biology : CB2008
Physical mechanisms redirecting cell polarity and cell shape in fission yeast.
Article in Current biology : CB, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers.
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Who cites it
38 citing papers in PubMed, 88 citations in OpenAlex.
- Interplay of ECM organization, ROCK signaling, and cell polarity drives mesothelium formation and lung growth.Nature communications · 2025Article
- Kinesin-4 optimizes microtubule orientations for responsive tip growth guidance in moss.The Journal of cell biology · 2023Article
- The interconnection of endoplasmic reticulum and microtubule and its implication in Hereditary Spastic Paraplegia.Computational and structural biotechnology journal · 2023Review
- Active condensation of filaments under spatial confinement.Frontiers in physics · 2022Article
- Ends and middle: Global force balance and septum location in fission yeast.The European physical journal. E, Soft matter · 2020Article
- Micro Versus Macro - The Effect of Environmental Confinement on Cellular Nanoparticle Uptake.Frontiers in bioengineering and biotechnology · 2020Article
- Local and global Cdc42 guanine nucleotide exchange factors for fission yeast cell polarity are coordinated by microtubules and the Tea1-Tea4-Pom1 axis.Journal of cell science · 2018Article
- Elongation and shape changes in organisms with cell walls: A dialogue between experiments and models.Cell surface (Amsterdam, Netherlands) · 2018Review
- Cell Polarity in Yeast.Annual review of cell and developmental biology · 2017Review
- Forces that shape fission yeast cells.Molecular biology of the cell · 2017Article
- Stress-stiffening-mediated stem-cell commitment switch in soft responsive hydrogels.Nature materials · 2016Article
- Microtubule minus end motors kinesin-14 and dynein drive nuclear congression in parallel pathways.The Journal of cell biology · 2015Article
- Light-dependent governance of cell shape dimensions in cyanobacteria.Frontiers in microbiology · 2015Review
- Experiments inside a box lead to out-of-the-box ideas on cellular organization.Systems and synthetic biology · 2014Article
- 3D-printed microfluidic microdissector for high-throughput studies of cellular aging.Analytical chemistry · 2014Article
- How and why cells grow as rods.BMC biology · 2014Review
- Stretching micropatterned cells on a PDMS membrane.Journal of visualized experiments : JoVE · 2014Article
- Dynamics of cell shape inheritance in fission yeast.PloS one · 2014Article
- Model of fission yeast cell shape driven by membrane-bound growth factors and the cytoskeleton.PLoS computational biology · 2013Article
- Growth propagation of yeast in linear arrays of microfluidic chambers over many generations.Biomicrofluidics · 2011Article
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Authors and funding
9 authors at 2 institutions in 2 countries.
Funding
Abstract
The cylindrical rod shape of the fission yeast Schizosaccharomyces pombe is organized and maintained by interactions between the microtubule, cell membrane, and actin cytoskeleton [1]. Mutations affecting any components in this pathway lead to bent, branched, or round cells [2]. In this context, the cytoskeleton controls cell polarity and thus dictates cell shape. Here, we use soft-lithography techniques to construct microfluidic channels to control cell shape. We show that when wild-type rod-shaped cells are physically forced to grow in a bent fashion, they will reorganize their cytoskeleton and redirect cell polarity to make new ectopic cell tips. Moreover, when bent or round mutant cells are physically forced to conform to the wild-type rod-shape, they will reverse their mutational phenotypes by reorganizing their cytoskeleton to maintain proper wild-type-like localization of microtubules, cell-membrane proteins, and actin. Our study provides direct evidence that the cytoskeleton controls cell polarity and cell shape and demonstrates that cell shape also controls the organization of the cytoskeleton in a feedback loop. We present a model of the feedback loop to explain how fission yeast maintain a rod shape and how perturbation of specific parameters of the loop can lead to different cell shapes.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.