ReviewEuropean journal of cancer (Oxford, England : 1990)2008
Molecular characterisation of the tumour microenvironment in breast cancer.
Review in European journal of cancer (Oxford, England : 1990), 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 60 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
60 citing papers in PubMed.
- Fibroblast Growth Factor-2 and the Invasive Potential in Urothelial Malignancies of the Bladder.Cureus · 2023Article
- Single-Cell RNA-Seq Reveals Heterogeneous lncRNA Expression in Xenografted Triple-Negative Breast Cancer Cells.Biology · 2021Article
- Recapitulating TumorigenesisFrontiers in bioengineering and biotechnology · 2021Review
- Three-dimensional models of breast cancer-fibroblasts interactions.Experimental biology and medicine (Maywood, N.J.) · 2020Review
- Functional Role of miRNAs in the Progression of Breast Ductal Carcinoma in Situ.The American journal of pathology · 2019Review
- An energy-blocking nanoparticle decorated with anti-VEGF antibody to reverse chemotherapeutic drug resistance.RSC advances · 2019Article
- Interleukin-8 Activates Breast Cancer-Associated Adipocytes and Promotes Their Angiogenesis- and Tumorigenesis-Promoting Effects.Molecular and cellular biology · 2019Article
- Transparent reporting of experimental parameters in assays measuring phenotypic steps in metastasis.Clinical & experimental metastasis · 2018Article
- The impact of contrast-enhanced spectral mammogram (CESM) and three-dimensional breast ultrasound (3DUS) on the characterization of the disease extend in cancer patients.The British journal of radiology · 2018Article
- Discriminating the earliest stages of mammary carcinoma using myoepithelial and proliferative markers.PloS one · 2018Article
- MIND model for triple-negative breast cancer in syngeneic mice for quick and sequential progression analysis of lung metastasis.PloS one · 2018Article
- Interactions between the tumor and the blood systemic response of breast cancer patients.PLoS computational biology · 2017Article
- Pathomimetic avatars reveal divergent roles of microenvironment in invasive transition of ductal carcinoma in situ.Breast cancer research : BCR · 2017Article
- CHEK2 represses breast stromal fibroblasts and their paracrine tumor-promoting effects through suppressing SDF-1 and IL-6.BMC cancer · 2016Article
- Article
- 3D culture of Her2+ breast cancer cells promotes AKT to MAPK switching and a loss of therapeutic response.BMC cancer · 2016Article
- Cancer stem cells and early stage basal-like breast cancer.World journal of obstetrics and gynecology · 2016Article
- PDGF-D promotes dermal fibroblast invasion in 3-dimensional extracellular matrix via Snail-mediated MT1-MMP upregulation.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2016Article
- Myoepithelial cell differentiation markers in ductal carcinoma in situ progression.The American journal of pathology · 2015Article
- IL-6 originated from breast cancer tissue-derived mesenchymal stromal cells may contribute to carcinogenesis.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2015Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
Abstract
The tumour microenvironment plays important roles in cancer initiation, growth, progression, invasion and metastasis, yet the molecular basis underlying these tumour-promoting effects is not fully delineated. Recent advances in gene expression, genetic and epigenetic profiling of stromal cells have improved our understanding of how mesenchymal-epithelial cell interactions may create a permissive microenvironment for malignancy and identified potential targets for cancer prevention and treatment including chemokine and cytokine networks. However, translating these findings into clinical practice may be difficult due to the complexity and redundancy of the interactions and the inherent ability of tumour epithelial cells to evolve and thrive in diverse environmental conditions.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.