ArticleGenetic epidemiology2009
A likelihood ratio test of population Hardy-Weinberg equilibrium for case-control studies.
Article in Genetic epidemiology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed.
- RAD-Seq-derived SSR markers: a new paradigm for genetic analysis and construction of genetically improved production populations in Pinus koraiensis.BMC plant biology · 2025Article
- Efficient test for deviation from Hardy-Weinberg equilibrium with known or ambiguous typing in highly polymorphic loci.Briefings in bioinformatics · 2024Article
- CYP4 subfamily V member 2 (CYP4V2) polymorphisms were associated with ischemic stroke in Chinese Han population.BMC medical genomics · 2022Article
- The NLRP3 Genetic Variant (rs10754555) Reduces the Risk of Adverse Outcome in Middle-Aged Patients with Chronic Coronary Syndrome.Journal of immunology research · 2022Observational
- Comment: "Evaluation of the Association of Omentin 1 rs2274907 A>T and rs2274908 G>A Gene Polymorphisms with Coronary Artery Disease in Indian Population: A Case Control Study".Journal of personalized medicine · 2020Article
- Genetic Diversity and Genetic Structure of the Wild Tsushima Leopard Cat from Genome-Wide Analysis.Animals : an open access journal from MDPI · 2020Article
- Article
- Heat Shock 70 Protein Genes and Genetic Susceptibility to Apical Periodontitis.Journal of endodontics · 2016Article
- Association Study between the CD157/BST1 Gene and Autism Spectrum Disorders in a Japanese Population.Brain sciences · 2015Article
- Analysis of multiple cytokine polymorphisms in individuals with untreated deep carious lesions reveals IL1B (rs1143643) as a susceptibility factor for periapical lesion development.Journal of endodontics · 2015Article
- Obesity-associated gene FTO rs9939609 polymorphism in relation to the risk of tuberculosis.BMC infectious diseases · 2014Article
- A shrinkage method for testing the Hardy-Weinberg equilibrium in case-control studies.Genetic epidemiology · 2013Article
- Genetic susceptibility to periapical disease: conditional contribution of MMP2 and MMP3 genes to the development of periapical lesions and healing response.Journal of endodontics · 2012Article
- Approximate and exact tests of Hardy-Weinberg equilibrium using uncertain genotypes.Genetic epidemiology · 2011Article
- Testing Hardy-Weinberg proportions in a frequency-matched case-control genetic association study.PloS one · 2011Article
- The number of markers in the HapMap project: some notes on chi-square and exact tests for Hardy-Weinberg equilibrium.American journal of human genetics · 2010Article
- Using both cases and controls for testing hardy-weinberg proportions in a genetic association study.Human heredity · 2010Article
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
Testing Hardy-Weinberg equilibrium (HWE) in the control group is commonly used to detect genotyping errors in genetic association studies. We propose a likelihood ratio test for testing HWE in the study population using both case and control samples. This test incorporates underlying association models. Another feature is that, when we infer the disease-genotype association, we explicitly incorporate HWE or a possible departure from Hardy-Weinberg equilibrium (DHWE) into the model. Our unified framework enables us to infer the disease-genotype association when a detected DHWE needs to be part of the model after causes for the DHWE are explored. Real data sets are used to illustrate the application of the methodology and its implication in genetic association studies. Our analysis and interpretation touch on issues such as genotyping errors, population selection, population stratification, or the study sampling plan, that all could be the cause of DHWE.
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