ArticleProceedings of the National Academy of Sciences of the United States of America1991
Splicing of juvenile and adult tau mRNA variants is regulated by thyroid hormone.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1991. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 83 citations in OpenAlex.
- Hypothyroidism and Diabetes-Related Dementia: Focused on Neuronal Dysfunction, Insulin Resistance, and Dyslipidemia.International journal of molecular sciences · 2022Review
- Review
- Thyroid Hormones in the Brain and Their Impact in Recovery Mechanisms After Stroke.Frontiers in neurology · 2019Review
- Isoform-independent and -dependent phosphorylation of microtubule-associated protein tau in mouse brain during postnatal development.The Journal of biological chemistry · 2018Article
- Maternal hormonal milieu influence on fetal brain development.Brain and behavior · 2018Review
- Potential Link Between Proprotein Convertase Subtilisin/Kexin Type 9 and Alzheimer's Disease.International journal of biomedical investigation · 2018Article
- Contribution of Brain Tissue Oxidative Damage in Hypothyroidism-associated Learning and Memory Impairments.Advanced biomedical research · 2017Review
- Cardiovascular risk factors and frontotemporal dementia: a case-control study.Translational neurodegeneration · 2014Article
- RNA helicase p68 (DDX5) regulates tau exon 10 splicing by modulating a stem-loop structure at the 5' splice site.Molecular and cellular biology · 2011Article
- Hypothyroidism induces selective oxidative stress in amygdala and hippocampus of rat.Metabolic brain disease · 2008Article
- Multigenic control of thyroid hormone functions in the nervous system.Molecular and cellular endocrinology · 2008Review
- Action of thyroid hormone in brain.Journal of endocrinological investigation · 2002Review
- Thyroid hormone regulates reelin and dab1 expression during brain development.The Journal of neuroscience : the official journal of the Society for Neuroscience · 1999Article
- The major transcription initiation site of the SV40 late promoter is a potent thyroid hormone response element.Nucleic acids research · 1997Article
- Thyroid hormone regulates Na+ currents in cultured hippocampal neurons from postnatal rats.Proceedings. Biological sciences · 1997Article
- Neonatal hypothyroidism affects the timely expression of myelin-associated glycoprotein in the rat brain.The Journal of clinical investigation · 1993Article
- Thyroid Hormone Enhances Neurite Outgrowth in Neuroscreen 1 Cells.International journal of biomedical investigationArticle
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The effect of thyroid hormone on the expression of tau transcripts was studied during postnatal brain development. The level of tau mRNA was only slightly changed postnatally in the cerebral hemispheres of hypothyroid rats, whereas the level of tau mRNA in the cerebellum was maintained at a higher level than in the euthyroid controls. As shown by in situ hybridization studies, such an alteration in tau mRNA expression can be ascribed to an effect of thyroid hormone on the rate of migration of the granule cells in the cerebellum; that tau mRNAs remain high in the cerebellum as long as the granule cells are migrating correlates with the observation that hypothyroidism slows the rate of migration of granule cells. RNase protection assays also showed that thyroid hormone deficiency delays the transition between the immature and mature tau transcripts in both brain regions. Thus, one of the effects of thyroid hormone is to regulate the splicing mechanism that allows replacement of the juvenile tau variants by the adult entities during neuronal differentiation.
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