ArticleJournal of neuroscience research2009
Interplay of hormones and p53 in modulating gender dimorphism of subventricular zone cell number.
Article in Journal of neuroscience research, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
14 citing papers in PubMed, 19 citations in OpenAlex.
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- Sex Disparities in P53 Regulation and Functions: Novel Insights for Personalized Cancer Therapies.Cells · 2025Review
- Sex bias in tumor immunity: insights from immune cells.Theranostics · 2025Review
- Genomic regions and biological pathways associated with sex-limited reproductive traits in bovine species.Journal of animal science · 2024Article
- Sex- and mutation-specific p53 gain-of-function activity in gliomagenesis.Cancer research communications · 2021Article
- 3D Image Analysis of the Complete Ventricular-Subventricular Zone Stem Cell Niche Reveals Significant Vasculature Changes and Progenitor Deficits in Males Versus Females with Aging.Stem cell reports · 2021Article
- Sex differences in cancer mechanisms.Biology of sex differences · 2020Review
- Testosterone and Adult Neurogenesis.Biomolecules · 2020Review
- Vitronectin mitigates stroke-increased neurogenesis only in female mice and through FAK-regulated IL-6.Experimental neurology · 2020Article
- Sex Differences in Brain Injury and Repair in Newborn Infants: Clinical Evidence and Biological Mechanisms.Frontiers in pediatrics · 2019Review
- Sex Steroids and Adult Neurogenesis in the Ventricular-Subventricular Zone.Frontiers in endocrinology · 2018Review
- Systemic injection of CD34(+)-enriched human cord blood cells modulates poststroke neural and glial response in a sex-dependent manner in CD1 mice.Stem cells and development · 2015Article
- Environmental enrichment rescues postnatal neurogenesis defect in the male and female Ts65Dn mouse model of Down syndrome.Developmental neuroscience · 2011Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Previous studies have suggested the existence of a gender bias in repair after demyelination. Here we report the existence of gender dimorphism for the regulation of cell number in the subventricular zone (SVZ), an area that has been studied for its repair potential. The number of Sox2(+) multipotential cells in the SVZ of young adult female mice was greater than in age-matched male siblings, but this difference was not evident prior to the surge of sex hormones (i.e., in prepubertal mice). To begin asking whether hormonally derived signals were responsible for these gender-related differences, we analyzed proliferation and survival of cultured male- and female-derived SVZ cells. Estrogen, but not testosterone treatment increased cell proliferation and survival of cultured cells after IFN-gamma treatment or after UV irradiation, regardless of the gender of origin. Because apoptosis in UV-irradiated SVZ cells correlated with the expression of the proapoptotic molecule p53, we postulated that this molecule could be responsible for the gender dimorphism in the SVZ. In agreement with this prediction, no difference in the SVZ cell number was detected in male and female p53 null mice. Together with previous reports, these results implicate p53 as an important component of the mechanism regulating gender dimorphism in the SVZ.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.