ArticleProceedings of the National Academy of Sciences of the United States of America1991
Human brain prostaglandin D synthase has been evolutionarily differentiated from lipophilic-ligand carrier proteins.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1991. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.
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Who cites it
35 citing papers in PubMed.
- Drug Delivery System for the Anticancer Drug Paclitaxel Using Lipocalin-Type Prostaglandin D Synthase Conjugated to a Tumor-Targeting Peptide.ACS omega · 2026Article
- Distinct Immunological Features Compared to Lichen Planus and Oral Lichen Planus.Journal of inflammation research · 2025Article
- Article
- Biochemical and Structural Characteristics, Gene Regulation, Physiological, Pathological and Clinical Features of Lipocalin-Type Prostaglandin DFrontiers in physiology · 2021Review
- Lipocalin-type prostaglandin D synthase regulates light-induced phase advance of the central circadian rhythm in mice.Communications biology · 2020Article
- Genome-wide transcriptome analysis of hypothalamus in rats with inherited stress-induced arterial hypertension.BMC genetics · 2016Article
- Article
- Sexually dimorphic effects of ancestral exposure to vinclozolin on stress reactivity in rats.Endocrinology · 2014Article
- AMPK agonist AICAR improves cognition and motor coordination in young and aged mice.Learning & memory (Cold Spring Harbor, N.Y.) · 2014Article
- Dexamethasone protects neonatal hypoxic-ischemic brain injury via L-PGDS-dependent PGD2-DP1-pERK signaling pathway.PloS one · 2014Article
- Urinary proteome analysis of irritable bowel syndrome (IBS) symptom subgroups.Journal of proteome research · 2012Article
- Lipocalin-type prostaglandin D2 synthase protein regulates glial cell migration and morphology through myristoylated alanine-rich C-kinase substrate: prostaglandin D2-independent effects.The Journal of biological chemistry · 2012Article
- Nuclear inelastic scattering and Mössbauer spectroscopy as local probes for ligand binding modes and electronic properties in proteins: vibrational behavior of a ferriheme center inside a β-barrel protein.Journal of the American Chemical Society · 2012Article
- Enzymes of the cyclooxygenase pathways of prostanoid biosynthesis.Chemical reviews · 2011Review
- Divergent responses to peptidoglycans derived from different E. coli serotypes influence inflammatory outcome in trout, Oncorhynchus mykiss, macrophages.BMC genomics · 2011Article
- Effects of body weight and alcohol consumption on insulin sensitivity.Nutrition journal · 2010Article
- A structural basis for the pH-dependent xanthophyll cycle in Arabidopsis thaliana.The Plant cell · 2009Article
- Biochemical, functional, and pharmacological characterization of AT-56, an orally active and selective inhibitor of lipocalin-type prostaglandin D synthase.The Journal of biological chemistry · 2009Article
- An association analysis of murine anxiety genes in humans implicates novel candidate genes for anxiety disorders.Biological psychiatry · 2008Article
- The crystal structure of Arabidopsis thaliana allene oxide cyclase: insights into the oxylipin cyclization reaction.The Plant cell · 2006Article
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
cDNAs for glutathione-independent prostaglandin D synthase were isolated from cDNA libraries of human brain. The longest cDNA insert was 837 base pairs long and contained a coding region of 570 base pairs corresponding to 190 amino acid residues with a calculated Mr of 21,016. Between two cDNA inserts isolated from the two different libraries, nucleotide substitutions were observed at 16 positions, including conservative amino acid substitutions at 2 positions and nonconservative substitutions at 5 positions, indicating genetic heterogeneity of this enzyme in humans. The computer-assisted homology search revealed that the enzyme is a member of the lipocalin superfamily, comprising secretory hydrophobic molecule transporters, showing the greatest homology (28.8-29.4% identity; 51.3-53.1% similarity) to alpha 1-microglobulin among the members of this superfamily. In a phylogenetic tree of the superfamily, this enzyme, alpha 1-microglobulin, and the gamma chain of the complement component C8 form a cluster separate from the other 14 members. The two distinctive characteristics of glutathione-independent prostaglandin D synthase, as compared to the other members of this superfamily, are its enzymatic properties and its association with membranes that were probably acquired after evolutionary divergence of the two lipocalins. Based on the observed sequence homology, the tertiary structure of the enzyme was deduced to consist of an eight-stranded anti-parallel beta-barrel forming a hydrophobic pocket. Furthermore, the Cys-65 residue in the pocket, which is conserved only in the human and rat enzymes but not in other lipocalins, was considered to be a putative active site of the enzyme.
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