ArticleProceedings of the National Academy of Sciences of the United States of America1991
A post-transcriptional mechanism contributes to circadian cycling of a per-beta-galactosidase fusion protein.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1991. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
14 citing papers in PubMed.
- Article
- Ribonucleoprotein complexes that control circadian clocks.International journal of molecular sciences · 2013Review
- Drosophila TRPA1 functions in temperature control of circadian rhythm in pacemaker neurons.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2013Article
- Control of the hypoxic response in Drosophila melanogaster by the basic helix-loop-helix PAS protein similar.Molecular and cellular biology · 2002Article
- Article
- Multiple circadian-regulated elements contribute to cycling period gene expression in Drosophila.The EMBO journal · 1997Article
- A circadian enhancer mediates PER-dependent mRNA cycling in Drosophila melanogaster.Molecular and cellular biology · 1997Article
- Temporal and spatial expression patterns of transgenes containing increasing amounts of the Drosophila clock gene period and a lacZ reporter: mapping elements of the PER protein involved in circadian cycling.The Journal of neuroscience : the official journal of the Society for Neuroscience · 1997Article
- Control of lhc gene transcription by the circadian clock in Chlamydomonas reinhardtii.Plant molecular biology · 1994Article
- Constitutive overexpression of the Drosophila period protein inhibits period mRNA cycling.The EMBO journal · 1994Article
- Temporal phosphorylation of the Drosophila period protein.Proceedings of the National Academy of Sciences of the United States of America · 1994Article
- Circadian oscillations in period gene mRNA levels are transcriptionally regulated.Proceedings of the National Academy of Sciences of the United States of America · 1992Article
- A novel circadian phenotype based on firefly luciferase expression in transgenic plants.The Plant cell · 1992Article
- Behavioral and molecular analyses suggest that circadian output is disrupted by disconnected mutants in D. melanogaster.The EMBO journal · 1992Article
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
The period gene (per) of Drosophila melanogaster affects circadian rhythms. Circadian fluctuations in per mRNA levels are thought to contribute to circadian fluctuations in per protein levels in the heads of adult flies. To address the mechanisms underlying these oscillatory phenomena, we have analyzed RNA and protein cycling from two per-beta-galactosidase fusion genes. These studies demonstrate that 5' noncoding sequences from per are sufficient to cause the fusion mRNA levels to cycle in a wild-type (rhythmic) background. Protein cycling requires additional sequences derived from the per coding region. The data suggest that there is a per-dependent posttranscriptional mechanism that is under circadian clock control required for per protein levels to fluctuate in a rhythmic fashion.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.