ArticleRadiation oncology (London, England)2008
Radiation-induced skin injury in the animal model of scleroderma: implications for post-radiotherapy fibrosis.
Article in Radiation oncology (London, England), 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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Who cites it
28 citing papers in PubMed, 47 citations in OpenAlex.
- Murine Model of Radiation Dermatitis with Experimental Wound and Effects of Genistein.International journal of molecular sciences · 2026Article
- FLASH radiotherapy preserves systemic and tissue homeostasis while maintaining antitumor efficacy.BMC medicine · 2026Article
- Development of a Radiotherapy-Induced Wound Model in Wistar Rats: Simulating Post-Radiation Skin and Soft Tissue Complications for Therapeutic Evaluation.Biomedicines · 2026Article
- Mechanistic Perspectives on Radiation-Induced Skin Injury and the Protective Effects of Berberine.Journal of inflammation research · 2025Article
- Berberine in the treatment of radiation-induced skin injury: insights from proteomics and network pharmacology.Frontiers in pharmacology · 2025Article
- Advanced Technologies in Radiation Research.Radiation research · 2024Article
- Radiation-induced gastrointestinal and cutaneous injuries: understanding models, pathologies, assessments, and clinically accepted practices.International journal of radiation biology · 2024Article
- Characterization of cellular senescence in radiation ulcers and therapeutic effects of mesenchymal stem cell-derived conditioned medium.Burns & trauma · 2023Article
- Adipose-derived stem cells alleviate radiation-induced dermatitis by suppressing apoptosis and downregulating cathepsin F expression.Stem cell research & therapy · 2021Article
- X-ray-Based Techniques to Study the Nano-Bio Interface.ACS nano · 2021Article
- Low-intensity ultrasound combined with allogenic adipose-derived mesenchymal stem cells (AdMSCs) in radiation-induced skin injury treatment.Scientific reports · 2020Article
- The antifibrotic adipose-derived stromal cell: Grafted fat enriched with CD74+ adipose-derived stromal cells reduces chronic radiation-induced skin fibrosis.Stem cells translational medicine · 2020Article
- Cutaneous Radiation Injuries: Models, Assessment and Treatments.Radiation research · 2020Article
- Cutaneous Radiation Injuries: Models, Assessment and Treatments.Radiation research · 2020Article
- Establishment and characterization of a radiation-induced dermatitis rat model.Journal of cellular and molecular medicine · 2019Article
- Wound healing complications in oncological patients: perspectives for cellular therapy.Postepy dermatologii i alergologii · 2019Review
- Accelerated senescence in skin in a murine model of radiation-induced multi-organ injury.Journal of radiation research · 2017Article
- Adenosine A2A receptor plays an important role in radiation-induced dermal injury.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2016Article
- β-irradiation (¹⁶⁶Ho patch)-induced skin injury in mini-pigs: effects on NF-κB and COX-2 expression in the skin.Journal of veterinary science · 2015Article
- microRNA alterations driving acute and late stages of radiation-induced fibrosis in a murine skin model.International journal of radiation oncology, biology, physics · 2014Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
backgroundRadiation therapy is generally contraindicated for cancer patients with collagen vascular diseases (CVD) such as scleroderma due to an increased risk of fibrosis. The tight skin (TSK) mouse has skin which, in some respects, mimics that of patients with scleroderma. The skin radiation response of TSK mice has not been previously reported. If TSK mice are shown to have radiation sensitive skin, they may prove to be a useful model to examine the mechanisms underlying skin radiation injury, protection, mitigation and treatment.
methodsThe hind limbs of TSK and parental control C57BL/6 mice received a radiation exposure sufficient to cause approximately the same level of acute injury. Endpoints included skin damage scored using a non-linear, semi-quantitative scale and tissue fibrosis assessed by measuring passive leg extension. In addition, TGF-beta1 cytokine levels were measured monthly in skin tissue.
resultsContrary to our expectations, TSK mice were more resistant (i.e. 20%) to radiation than parental control mice. Although acute skin reactions were similar in both mouse strains, radiation injury in TSK mice continued to decrease with time such that several months after radiation there was significantly less skin damage and leg contraction compared to C57BL/6 mice (p < 0.05). Consistent with the expected association of transforming growth factor beta-1 (TGF-beta1) with late tissue injury, levels of the cytokine were significantly higher in the skin of the C57BL/6 mouse compared to TSK mouse at all time points (p < 0.05).
conclusionTSK mice are not recommended as a model of scleroderma involving radiation injury. The genetic and molecular basis for reduced radiation injury observed in TSK mice warrants further investigation particularly to identify mechanisms capable of reducing tissue fibrosis after radiation injury.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.