ArticleClinical infectious diseases : an official publication of the Infectious Diseases Society of America2009
Diagnosis of neurocysticercosis by detection of Taenia solium DNA using a global DNA screening platform.
Article in Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 26 citations in OpenAlex.
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- Microbial Identification Using DNA Target Amplification and Sequencing: Clinical Utility and Impact on Patient Management.Open forum infectious diseases · 2018Review
- Parasitology should not be abandoned: data from outpatient parasitological testing in Guangdong, China.Infectious diseases of poverty · 2017Article
- Molecular testing for clinical diagnosis and epidemiological investigations of intestinal parasitic infections.Clinical microbiology reviews · 2014Review
- Molecular diagnosis of Actinomadura madurae infection by 16S rRNA deep sequencing.Journal of clinical microbiology · 2013Article
- Cysticerci-related single parenchymal brain enhancing lesions in non-endemic countries.Journal of the neurological sciences · 2012Review
- Molecular diagnosis of subcutaneous Pythium insidiosum infection by use of PCR screening and DNA sequencing.Journal of clinical microbiology · 2012Article
- PCR test for detecting Taenia solium cysticercosis in pig carcasses.Tropical animal health and production · 2012Article
- Molecular diagnosis of cystoisosporiasis using extended-range PCR screening.The Journal of molecular diagnostics : JMD · 2011Article
- Surgical remotion of a cysticercotic granuloma responsible for refractory seizures: A case report.Surgical neurology international · 2011Article
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Authors and funding
6 authors at 1 institution in 1 country.
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Abstract
Neurocysticercosis is caused by Taenia solium infection of the brain. Diagnosis is most often made by visualization of the parasitic scolex by magnetic resonance imaging of the brain or by characteristic neuroimaging findings with serologic test results positive for T. solium. A patient who presents with a solitary brain lesion usually poses a diagnostic dilemma, because the differential diagnosis often includes neurocysticercosis and other infections or neoplasm. Although the sensitivity of serologic testing for T. solium approaches 100% in patients with multiple intraparenchymal cysts, the sensitivity of testing for patients with solitary cysts is <50%, which makes serologic testing a less useful diagnostic tool for patients with solitary central nervous system (CNS) lesions. We describe 2 patients with solitary CNS lesions who received a neurocysticercosis diagnosis after identification of T. solium DNA in brain biopsy tissue with use of a global DNA screening platform. Global screening is a promising tool for the diagnosis of CNS infection, especially when traditional diagnostic tools are insensitive.
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