ArticleJournal of abnormal psychology2008
Anhedonia as a phenotype for the Val158Met COMT polymorphism in relatives of patients with schizophrenia.
Article in Journal of abnormal psychology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 2 of them syntheses that pooled it.
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Who cites it
26 citing papers in PubMed, 2 syntheses or guidelines pooled it, 60 citations in OpenAlex.
- The Role of a Catechol-O-Methyltransferase (COMT) Val158Met Genetic Polymorphism in Schizophrenia: A Systematic Review and Updated Meta-analysis on 32,816 Subjects.Neuromolecular medicine · 2016Pooled it
- COMT Val(158) Met genotype is associated with reward learning: a replication study and meta-analysis.Genes, brain, and behavior · 2016Pooled it
- Understanding Anhedonia from a Genomic Perspective.Current topics in behavioral neurosciences · 2022Review
- The Associations between COMT and MAO-B Genetic Variants with Negative Symptoms in Patients with Schizophrenia.Current issues in molecular biology · 2021Article
- Neural anomalies during vigilance in schizophrenia: Diagnostic specificity and genetic associations.NeuroImage. Clinical · 2020Article
- Exploring the Relationship of Transdiagnostic Mood and Psychosis Symptom Domains with Motor Dysfunction.Neuropsychobiology · 2020Article
- Instrument-based assessment of motor function yields no evidence of dyskinesia in adult first-degree biological relatives of individuals with schizophrenia and schizoaffective disorder.Psychiatry research · 2019Article
- A Transdiagnostic Perspective on Social Anhedonia.Frontiers in psychiatry · 2019Review
- Polygenic prediction of the phenome, across ancestry, in emerging adulthood.Psychological medicine · 2018Article
- The neural transfer effect of working memory training to enhance hedonic processing in individuals with social anhedonia.Scientific reports · 2016Article
- Cross-Disorder Psychiatric Genomics.Current behavioral neuroscience reports · 2016Article
- Evidence of structural invariance across three groups of Meehlian schizotypes.NPJ schizophrenia · 2016Article
- Neurobiological background of negative symptoms.European archives of psychiatry and clinical neuroscience · 2015Review
- The role of schizotypy in the study of the etiology of schizophrenia spectrum disorders.Schizophrenia bulletin · 2015Review
- Self-reported affective traits and current affective experiences of biological relatives of people with schizophrenia.Schizophrenia research · 2015Article
- COMT-by-sex interaction effect on psychosis proneness.BioMed research international · 2015Article
- Prefrontal inefficiency is associated with polygenic risk for schizophrenia.Schizophrenia bulletin · 2014Article
- The paradox of schizotypy: resemblance to prolonged severe mental illness in subjective but not objective quality of life.Psychiatry research · 2014Article
- Schizotypal personality disorder: a current review.Current psychiatry reports · 2014Review
- An Overview of the Association between Schizotypy and Dopamine.Frontiers in psychiatry · 2014Review
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
The Val(158)Met polymorphism of the catechol-O-methyltransferase (COMT) gene has been associated with aspects of schizophrenia that are possibly related to the disorder's pathogenesis. The present study investigated the Val(158)Met polymorphism in relation to anhedonia--a construct central to negative schizotypy. Anhedonia and other schizotypal characteristics were assessed in relatives of patients with schizophrenia, relatives of patients with bipolar disorder, and nonpsychiatric controls using the Chapman schizotypy scales and the Schizotypal Personality Questionnaire. Compared with controls, relatives of individuals with schizophrenia had elevated scores on Chapman scales for social anhedonia and physical anhedonia, while relatives of patients with bipolar disorder exhibited only increased scores on the Social Anhedonia Scale. As a group, relatives of patients with schizophrenia who were homozygous for the val allele of the COMT polymorphism showed the highest elevations in self-reported social and physical anhedonia. Associations with the COMT polymorphism were absent in relatives of patients with bipolar disorder and control participants. Findings suggest that anhedonia is manifest in individuals who carry genetic liability for schizophrenia and is associated with the Val(158)Met polymorphism of the COMT gene.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.