ArticleThe Journal of experimental medicine1991
Deletions of immunoglobulin C kappa region characterized by the circular excision products in mouse splenocytes.
Article in The Journal of experimental medicine, 1991. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
18 citing papers in PubMed, 40 citations in OpenAlex.
- VprBP (DCAF1) Regulates RAG1 Expression Independently of Dicer by Mediating RAG1 Degradation.Journal of immunology (Baltimore, Md. : 1950) · 2018Article
- Violation of the 12/23 rule of genomic V(D)J recombination is common in lymphocytes.Genome research · 2015Article
- Central B-cell tolerance: where selection begins.Cold Spring Harbor perspectives in biology · 2012Article
- A new hypersensitive site, HS10, and the enhancers, E3' and Ed, differentially regulate Igκ gene expression.Journal of immunology (Baltimore, Md. : 1950) · 2012Article
- The Igκ gene enhancers, E3' and Ed, are essential for triggering transcription.Journal of immunology (Baltimore, Md. : 1950) · 2010Article
- Violations of the 12/23 rule at the mouse immunoglobulin kappa locus, including V kappa-V kappa rearrangement.Molecular immunology · 2009Article
- Conserved cryptic recombination signals in Vkappa gene segments are cleaved in small pre-B cells.BMC immunology · 2009Article
- Article
- Multiple, conserved cryptic recombination signals in VH gene segments: detection of cleavage products only in pro B cells.The Journal of experimental medicine · 2007Article
- Replication history of B lymphocytes reveals homeostatic proliferation and extensive antigen-induced B cell expansion.The Journal of experimental medicine · 2007Article
- Structure of the catfish IGH locus: analysis of the region including the single functional IGHM gene.Immunogenetics · 2006Article
- Diverse immunoglobulin light chain organizations in fish retain potential to revise B cell receptor specificities.Journal of immunology (Baltimore, Md. : 1950) · 2006Article
- Receptor selection in B and T lymphocytes.Annual review of immunology · 2000Review
- Receptor editing occurs frequently during normal B cell development.The Journal of experimental medicine · 1998Article
- Cryptic signals and the fidelity of V(D)J joining.Molecular and cellular biology · 1997Article
- Deletion of the immunoglobulin kappa chain intron enhancer abolishes kappa chain gene rearrangement in cis but not lambda chain gene rearrangement in trans.The EMBO journal · 1993Article
- New nucleotide sequence data on the EMBL File Server.Nucleic acids research · 1992Article
- Analysis of expressed and non-expressed IGK locus rearrangements in chronic lymphocytic leukemia.Molecular medicine (Cambridge, Mass.)Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We have identified circular DNAs containing the kappa light chain constant region (C kappa), as well as the excision products of V kappa-J kappa and V lambda-J lambda joining in adult mouse splenocytes. Analysis of C kappa-positive circular DNA clones revealed two recombination sites (intron recombining sequence [IRS]1 and -2) within the germline J kappa-C kappa intron region and the recombining sequence (RS) located downstream of the C kappa exon. While RS contains a conserved heptamer and nonamer separated by a 23-bp spacer on the 5' side, IRS1 sequence is an isolated heptamer without an obvious nonamer, and IRS2 contains a variant heptamer, CACAAAA. Since IRS1 and IRS2 recombined with both RS (23-bp spacer signal) and V kappa (12-bp spacer signal) with significant frequency, intron recombination sites seem to have dual recombination signals. These findings provide direct evidence that C kappa deletion preceding lambda gene rearrangement can occur by looping out and excision. Increased accessibility of inefficient recombinational loci within the intron may enable recombinase to accept wide signal sequence variation.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.