ArticleJournal of cell communication and signaling2008
Expression and function of alphabeta1 integrins in pancretic beta (INS-1) cells.
Article in Journal of cell communication and signaling, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
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Who cites it
21 citing papers in PubMed, 55 citations in OpenAlex.
- Role of small intronic RNAs in the crosstalk between immune cells and β-cells during type 1 diabetes development.RNA biology · 2026Article
- Extracellular matrix from decellularized porcine organs as scaffolds for insulin-secreting cells and pancreatic islets.Frontiers in endocrinology · 2025Article
- ECM Proteins Nidogen-1 and Decorin Restore Functionality of Human Islets of Langerhans upon Hypoxic Conditions.Advanced healthcare materials · 2025Article
- Insulin secretion hot spots in pancreatic β cells as secreting adhesions.Frontiers in cell and developmental biology · 2023Article
- Insulin enhances neurite extension and myelination of diabetic neuropathy neurons.The Korean journal of pain · 2022Article
- Organization and dynamics of the cortical complexes controlling insulin secretion in β-cells.Journal of cell science · 2022Article
- Collagen IV-β1-Integrin Influences INS-1 Cell Insulin SecretionFrontiers in cell and developmental biology · 2022Article
- Activation of Pancreatic Stellate Cells Is Beneficial for Exocrine but Not Endocrine Cell Differentiation in the Developing Human Pancreas.Frontiers in cell and developmental biology · 2021Article
- Extracellular Matrix-Associated Factors Play Critical Roles in Regulating Pancreatic β-Cell Proliferation and Survival.Endocrinology · 2019Review
- The adhesion receptor GPR56 is activated by extracellular matrix collagen III to improve β-cell function.Cellular and molecular life sciences : CMLS · 2018Article
- Identification of novel high-impact recessively inherited type 2 diabetes risk variants in the Greenlandic population.Diabetologia · 2018Article
- Extracellular matrix molecules and their potential contribution to the function of transplanted pancreatic islets.Diabetologia · 2018Review
- Therapeutic Strategies for Modulating the Extracellular Matrix to Improve Pancreatic Islet Function and Survival After Transplantation.Current diabetes reports · 2018Review
- Article
- Islet Endothelial Cells Induce Glycosylation and Increase Cell-surface Expression of Integrin β1 in β Cells.The Journal of biological chemistry · 2015Article
- Maintaining human fetal pancreatic stellate cell function and proliferation require β1 integrin and collagen I matrix interactions.Oncotarget · 2015Article
- Maintenance of ischemic β cell viability through delivery of lipids and ATP by targeted liposomes.Biomaterials science · 2014Article
- Microenvironmental stimuli for proliferation of functional islet β-cells.Cell & bioscience · 2014Article
- Article
- Inhibition of Gsk3β activity improves β-cell function in c-KitWv/+ male mice.Laboratory investigation; a journal of technical methods and pathology · 2012Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Integrin-extracellular matrix interactions are important determinants of beta cell behaviours. The beta1 integrin is a well-known regulator of beta cell activities; however, little is known of its associated alpha subunits. In the present study, alphabeta1 integrin expression was examined in the rat insulinoma cell line (INS-1) to identify their role in beta cell survival and function. Seven alpha subunits associated with beta1 integrin were identified, including alpha1-6 and alphaV. Among these heterodimers, alpha3beta1 was most highly expressed. Common ligands for the alpha3beta1 integrin, including fibronectin, laminin, collagen I and collagen IV were tested to identify the most suitable matrix for INS-1 cell proliferation and function. Cells exposed to collagen I and IV demonstrated significant increases in adhesion, spreading, cell viability, proliferation, and FAK phosphorylation when compared to cells cultured on fibronectin, laminin and controls. Integrin-dependent attachment also had a beneficial effect on beta cell function, increasing Pdx-1 and insulin gene and protein expression on collagens I and IV, in parallel with increased basal insulin release and enhanced insulin secretion upon high glucose challenge. Furthermore, functional blockade of alpha3beta1 integrin decreased cell adhesion, spreading and viability on both collagens and reduced Pdx-1 and insulin expression, indicating that its interactions with collagen matrices are important for beta cell survival and function. These results demonstrate that specific alphabeta1 integrin-ECM interactions are critical regulators of INS-1 beta cell survival and function and will be important in designing optimal conditions for cell-based therapies for diabetes treatment.
Identifiers
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.