ReviewChromosoma2009
RNA turnover and chromatin-dependent gene silencing.
Review in Chromosoma, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed, 42 citations in OpenAlex.
- Catalytic activities, molecular connections, and biological functions of plant RNA exosome complexes.The Plant cell · 2022Review
- Article
- Long-term experimental evolution reveals purifying selection on piRNA-mediated control of transposable element expression.BMC biology · 2020Article
- Architectural RNA in chromatin organization.Biochemical Society transactions · 2020Review
- LSM2-8 and XRN-2 contribute to the silencing of H3K27me3-marked genes through targeted RNA decay.Nature cell biology · 2020Article
- Nuclear Ccr4-Not mediates the degradation of telomeric and transposon transcripts at chromatin in the Drosophila germline.Nucleic acids research · 2020Article
- Comparative cytogenetic of six species of Amazonian Peacock bass (Comparative cytogenetics · 2020Article
- Molecular mechanisms of epigenetic inheritance: Possible evolutionary implications.Seminars in cell & developmental biology · 2020Review
- Genomic Organization Under Different Environmental Conditions: Hoplosternum Littorale as a Model.Zebrafish · 2016Article
- Differential repetitive DNA composition in the centromeric region of chromosomes of Amazonian lizard species in the family Teiidae.Comparative cytogenetics · 2016Article
- H3K9 methylation extends across natural boundaries of heterochromatin in the absence of an HP1 protein.The EMBO journal · 2015Article
- mRNA quality control goes transcriptional.Biochemical Society transactions · 2013Review
- Chromatin-associated ncRNA activities.Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology · 2013Review
- Heterochromatic gene silencing by activator interference and a transcription elongation barrier.The Journal of biological chemistry · 2013Article
- Cytogenetics of Synbranchiformes: a comparative analysis of two Synbranchus Bloch, 1795 species from the Amazon.Genetica · 2012Article
- Dicer associates with chromatin to repress genome activity in Schizosaccharomyces pombe.Nature structural & molecular biology · 2011Article
- Interaction of noncoding RNA with the rDNA promoter mediates recruitment of DNMT3b and silencing of rRNA genes.Genes & development · 2010Article
- Proteomic and functional analysis of the noncanonical poly(A) polymerase Cid14.RNA (New York, N.Y.) · 2010Article
- Long intronic GAA repeats causing Friedreich ataxia impede transcription elongation.EMBO molecular medicine · 2010Article
- Epigenome manipulation as a pathway to new natural product scaffolds and their congeners.Natural product reports · 2010Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Over the last few years, there has been a convergence of two seemingly disparate fields of study: chromatin-dependent gene silencing and RNA turnover. In contrast to RNA turnover mechanisms that operate on a truly posttranscriptional level, we are at the beginning of studies leading the way toward a model in which RNA turnover mechanisms are also involved in chromatin-dependent gene regulation. In particular, data from a variety of organisms have shown that the assembly of silent chromatin coincides with the presence or absence of non-protein-coding RNAs (ncRNAs). These range from long ncRNAs that have been classically implicated in the regulation of dosage compensation and genomic imprinting to small ncRNAs which are involved in heterochromatin assembly via the RNA interference (RNAi) pathway. This raises the question of how common ncRNAs are used to control gene expression at the level of chromatin. It is known at least, that they are present, as recent findings indicate that transcription of eukaryotic genomes is much more widespread than previously anticipated. However, the existence of a ncRNA does not prove its biological significance. Thus, a future challenge will be to distinguish the ncRNAs that are in some way meaningful to the organism from those that arise from the imperfect fidelity of the transcription machinery. Finally, no matter whether functional or not, RNAs transcribed from supposedly silent chromatin seem to be processed rapidly. Recent data from both fission and budding yeast suggest that chromatin-dependent gene silencing is achieved, at least in part, through RNA turnover mechanisms that use components of the RNAi pathway as well as polyadenylation-dependent RNA decay. Hence, silent chromatin is not only controlled transcriptionally, but also on co- and posttranscriptional levels.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.