ArticlePLoS pathogens2008
Role of amphipathic helix of a herpesviral protein in membrane deformation and T cell receptor downregulation.
Article in PLoS pathogens, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
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Who cites it
21 citing papers in PubMed, 29 citations in OpenAlex.
- Characterization of a Cytokine-Independent STAT5 Activator.Biomedicines · 2026Article
- An engineered viral protein activates STAT5 to prevent T cell suppression.Science immunology · 2025Article
- Antigen B from Echinococcus granulosus enters mammalian cells by endocytic pathways.PLoS neglected tropical diseases · 2018Article
- Structure of a lipid A phosphoethanolamine transferase suggests how conformational changes govern substrate binding.Proceedings of the National Academy of Sciences of the United States of America · 2017Article
- The Modulation of Apoptotic Pathways by Gammaherpesviruses.Frontiers in microbiology · 2016Review
- A membrane proximal helix in the cytosolic domain of the human APP interacting protein LR11/SorLA deforms liposomes.Biochimica et biophysica acta · 2015Article
- Modulating p56Lck in T-Cells by a Chimeric Peptide Comprising Two Functionally Different Motifs of Tip from Herpesvirus saimiri.Journal of immunology research · 2015Article
- The arginine-rich N-terminal domain of ROP18 is necessary for vacuole targeting and virulence of Toxoplasma gondii.Cellular microbiology · 2012Article
- Activation of the STAT6 transcription factor in Jurkat T-cells by the herpesvirus saimiri Tip protein.The Journal of general virology · 2012Article
- Bilateral inhibition of HAUSP deubiquitinase by a viral interferon regulatory factor protein.Nature structural & molecular biology · 2011Article
- Inhibition of retromer activity by herpesvirus saimiri tip leads to CD4 downregulation and efficient T cell transformation.Journal of virology · 2011Article
- Exosomes/microvesicles: mediators of cancer-associated immunosuppressive microenvironments.Seminars in immunopathology · 2011Review
- Intracellular lipid flux and membrane microdomains as organizing principles in inflammatory cell signaling.Journal of immunology (Baltimore, Md. : 1950) · 2011Review
- Influenza virus assembly and budding.Virology · 2011Review
- Membrane curvature during peroxisome fission requires Pex11.The EMBO journal · 2011Article
- Function of membrane rafts in viral lifecycles and host cellular response.Biochemistry research international · 2011Article
- The SCHOOL of nature: IV. Learning from viruses.Self/nonself · 2010Article
- Influenza virus m2 ion channel protein is necessary for filamentous virion formation.Journal of virology · 2010Article
- Novel mechanistic insights into viral modulation of immune receptor signaling.PLoS pathogens · 2009Article
- New therapeutic strategies targeting transmembrane signal transduction in the immune system.Cell adhesion & migrationReview
Corrections and comments
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Authors and funding
13 authors at 5 institutions in 2 countries.
Funding
Abstract
Lipid rafts are membrane microdomains that function as platforms for signal transduction and membrane trafficking. Tyrosine kinase interacting protein (Tip) of T lymphotropic Herpesvirus saimiri (HVS) is targeted to lipid rafts in T cells and downregulates TCR and CD4 surface expression. Here, we report that the membrane-proximal amphipathic helix preceding Tip's transmembrane (TM) domain mediates lipid raft localization and membrane deformation. In turn, this motif directs Tip's lysosomal trafficking and selective TCR downregulation. The amphipathic helix binds to the negatively charged lipids and induces liposome tubulation, the TM domain mediates oligomerization, and cooperation of the membrane-proximal helix with the TM domain is sufficient for localization to lipid rafts and lysosomal compartments, especially the mutivesicular bodies. These findings suggest that the membrane-proximal amphipathic helix and TM domain provide HVS Tip with the unique ability to deform the cellular membranes in lipid rafts and to downregulate TCRs potentially through MVB formation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.