ArticlePLoS computational biology2008
Order-based representation in random networks of cortical neurons.
Article in PLoS computational biology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers.
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Who cites it
38 citing papers in PubMed.
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- Mecp2 deficiency impairs microscale cortical network topology and dynamics in a Rett syndrome mouse model.bioRxiv : the preprint server for biology · 2025Article
- Microfluidic Bi-Layer Platform to Study Functional Interaction between Co-Cultured Neural Networks with Unidirectional Synaptic Connectivity.Micromachines · 2023Article
- Stimulus-Evoked Activity Modulation of In Vitro Engineered Cortical and Hippocampal Networks.Micromachines · 2022Article
- Neural synchrony in cortical networks: mechanisms and implications for neural information processing and coding.Frontiers in integrative neuroscience · 2022Article
- A Theoretical Comprehensive Framework for the Process of Theories Formation.Computational intelligence and neuroscience · 2021Review
- Unstructured network topology begets order-based representation by privileged neurons.Biological cybernetics · 2020Article
- Spatial Properties of STDP in a Self-Learning Spiking Neural Network Enable Controlling a Mobile Robot.Frontiers in neuroscience · 2020Article
- A Biohybrid Setup for Coupling Biological and Neuromorphic Neural Networks.Frontiers in neuroscience · 2019Article
- Functional Scaffolding for Brain Implants: Engineered Neuronal Network by Microfabrication and iPSC Technology.Frontiers in neuroscience · 2019Article
- Inhomogeneities in Network Structure and Excitability Govern Initiation and Propagation of Spontaneous Burst Activity.Frontiers in neuroscience · 2019Article
- Theta rhythm-like bidirectional cycling dynamics of living neuronal networks in vitro.PloS one · 2018Article
- Stimulation triggers endogenous activity patterns in cultured cortical networks.Scientific reports · 2017Article
- Mesoscale Architecture Shapes Initiation and Richness of Spontaneous Network Activity.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2017Article
- Development of Cortical Networks under Continuous Stimulation.Frontiers in molecular neuroscience · 2017Article
- Selectivity of stimulus induced responses in cultured hippocampal networks on microelectrode arrays.Cognitive neurodynamics · 2016Article
- A Possible Common Neurophysiologic Basis for MDD, Bipolar Disorder, and Schizophrenia: Lessons from Electrophysiology.Frontiers in psychiatry · 2016Article
- Repeated stimulation of cultured networks of rat cortical neurons induces parallel memory traces.Learning & memory (Cold Spring Harbor, N.Y.) · 2015Article
- Interaction of electrically evoked activity with intrinsic dynamics of cultured cortical networks with and without functional fast GABAergic synaptic transmission.Frontiers in cellular neuroscience · 2015Article
- Stimulus information stored in lasting active and hidden network states is destroyed by network bursts.Frontiers in integrative neuroscience · 2015Article
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The wide range of time scales involved in neural excitability and synaptic transmission might lead to ongoing change in the temporal structure of responses to recurring stimulus presentations on a trial-to-trial basis. This is probably the most severe biophysical constraint on putative time-based primitives of stimulus representation in neuronal networks. Here we show that in spontaneously developing large-scale random networks of cortical neurons in vitro the order in which neurons are recruited following each stimulus is a naturally emerging representation primitive that is invariant to significant temporal changes in spike times. With a relatively small number of randomly sampled neurons, the information about stimulus position is fully retrievable from the recruitment order. The effective connectivity that makes order-based representation invariant to time warping is characterized by the existence of stations through which activity is required to pass in order to propagate further into the network. This study uncovers a simple invariant in a noisy biological network in vitro; its applicability under in vivo constraints remains to be seen.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.