ArticleAmerican journal of epidemiology2009
Invited commentary: from genome-wide association studies to gene-environment-wide interaction studies--challenges and opportunities.
Article in American journal of epidemiology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 80 papers, 4 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
80 citing papers in PubMed, 4 syntheses or guidelines pooled it.
- Gene-Environment Interactions in Vitamin D Status and Sun Exposure: A Systematic Review with Recommendations for Future Research.Nutrients · 2022Pooled it
- What is the evidence for interactions between filaggrin null mutations and environmental exposures in the aetiology of atopic dermatitis? A systematic review.The British journal of dermatology · 2020Pooled it
- Review of the Gene-Environment Interaction Literature in Cancer: What Do We Know?Genetic epidemiology · 2016Pooled it
- A systematic review of cancer GWAS and candidate gene meta-analyses reveals limited overlap but similar effect sizes.European journal of human genetics : EJHG · 2014Pooled it
- Marginal interaction test for detecting interactions between genetic marker sets and environment in genome-wide studies.G3 (Bethesda, Md.) · 2025Article
- A review of common statistical methods for dealing with multiple pollutant mixtures and multiple exposures.Frontiers in public health · 2024Review
- Genetics of neurosarcoidosis.Journal of neuroimmunology · 2022Review
- Genetic Interactions with Intrauterine Diabetes Exposure in Relation to Obesity: The EPOCH and Project Viva Studies.Pediatric reports · 2021Article
- The Evolving Field of Genetic Epidemiology: From Familial Aggregation to Genomic Sequencing.American journal of epidemiology · 2019Review
- Genome-wide association studies of structural birth defects: A review and commentary.Birth defects research · 2019Review
- Extended methods for gene-environment-wide interaction scans in studies of admixed individuals with varying degrees of relationships.Genetic epidemiology · 2019Article
- Interpretation of the hygiene and microflora hypothesis for allergic diseases through epigenetic epidemiology.Epidemiology and health · 2018Article
- Construction of environmental risk score beyond standard linear models using machine learning methods: application to metal mixtures, oxidative stress and cardiovascular disease in NHANES.Environmental health : a global access science source · 2017Article
- Opportunities and Challenges for Environmental Exposure Assessment in Population-Based Studies.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2017Review
- What Does "Precision Medicine" Have to Say About Prevention?Epidemiology (Cambridge, Mass.) · 2017Article
- Evidence for large-scale gene-by-smoking interaction effects on pulmonary function.International journal of epidemiology · 2017Article
- The social genome: Current findings and implications for the study of human genetics.PLoS genetics · 2017Article
- Gene-Environment Interactions-What Can These Tell Us about the Relationship between Asthma and Allergy?Frontiers in pediatrics · 2017Review
- The OncoArray Consortium: A Network for Understanding the Genetic Architecture of Common Cancers.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2017Review
- The importance of gene-environment interactions in human obesity.Clinical science (London, England : 1979) · 2016Review
20 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
2 authors.
Funding
Abstract
The recent success of genome-wide association studies in finding susceptibility genes for many common diseases presents tremendous opportunities for epidemiologic studies of environmental risk factors. Analysis of gene-environment interactions, included in only a small fraction of epidemiologic studies until now, will begin to accelerate as investigators integrate analyses of genome-wide variation and environmental factors. Nevertheless, considerable methodological challenges are involved in the design and analysis of gene-environment interaction studies. The authors review these issues in the context of evolving methods for assessing interactions and discuss how the current agnostic approach to interrogating the human genome for genetic risk factors could be extended into a similar approach to gene-environment-wide interaction studies of disease occurrence in human populations.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.