ArticleAngiology
Effect of weight reduction with dietary intervention on arterial distensibility and endothelial function in obese men.
Article in Angiology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It reports registered trial NCT02633488. Cited by 20 papers, 2 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Effect of Metformin on Insulin Sensitivity and Pan-Arterial Vascular Function in Adults With Metabolic Syndrome
The Effect of Type 1 Diabetes on Pan-Arterial Vascular Function and Insulin Sensitivity in Humans
The Impact of Fitness and Mineralocorticoid Receptor Blockade on Vascular Dysfunction in Adults With Type 1 Diabetes
Who cites it
20 citing papers in PubMed, 2 syntheses or guidelines pooled it, 71 citations in OpenAlex.
- Effects of dietary-based weight loss interventions on biomarkers of endothelial function: a systematic review and meta-analysis.European journal of clinical nutrition · 2023Pooled it
- Effect of aerobic exercise training on arterial stiffness in obese populations : a systematic review and meta-analysis.Sports medicine (Auckland, N.Z.) · 2014Pooled it
- Elevated pentraxin 3 level at the early stage of exercise training is associated with reduction of arterial stiffness in middle-aged and older adults.Journal of human hypertension · 2016Trial
- Effects of Resistance Training With and Without Caloric Restriction on Arterial Stiffness in Overweight and Obese Older Adults.American journal of hypertension · 2016Trial
- Effects of an intensive behavioral weight loss intervention consisting of caloric restriction with or without physical activity on common carotid artery remodeling in severely obese adults.Metabolism: clinical and experimental · 2012Trial
- Effects of weight loss and insulin reduction on arterial stiffness in the SAVE trial.Cardiovascular diabetology · 2012Trial
- Physical exercise, fitness and dietary pattern and their relationship with circadian blood pressure pattern, augmentation index and endothelial dysfunction biological markers: EVIDENT study protocol.BMC public health · 2010Trial
- Arterial destiffening with weight loss in overweight and obese middle-aged and older adults.Hypertension (Dallas, Tex. : 1979) · 2010Trial
- Intense Caloric Restriction from Birth Protects the Heart Against Ischemia/Reperfusion Injury and Reduces Reactive Oxygen Species in Ovariectomized Rats.Antioxidants (Basel, Switzerland) · 2025Article
- Body Composition Indices and Cardiovascular Risk in Type 2 Diabetes. CV Biomarkers are not Related to Body Composition.Open medicine (Warsaw, Poland) · 2020Article
- Dietary modification reduces serum angiopoietin-like protein 2 levels and arterial stiffness in overweight and obese men.Journal of exercise nutrition & biochemistry · 2019Article
- Short-term weight loss reverses obesity-induced microvascular endothelial dysfunction.GeroScience · 2018Article
- Relationships between serum free fatty acid and pulse pressure amplification in overweight/obese men: insights from exercise training and dietary modification.Journal of clinical biochemistry and nutrition · 2018Article
- Endothelial Regenerative Capacity and Aging: Influence of Diet, Exercise and Obesity.Current cardiology reviews · 2018Review
- Increased physical activity has a greater effect than reduced energy intake on lifestyle modification-induced increases in testosterone.Journal of clinical biochemistry and nutrition · 2016Article
- Weight Loss, Dietary Intake and Pulse Wave Velocity.Pulse (Basel, Switzerland) · 2015Review
- Non-invasive assessment of arterial stiffness using oscillometric blood pressure measurement.Biomedical engineering online · 2012Article
- Caloric restriction and chronic inflammatory diseases.Oral diseases · 2012Review
- Increased serum nitric oxide concentration after bariatric surgery--a potential mechanism for cardiovascular benefit.Obesity surgery · 2010Article
- Anti-oxidative and anti-inflammatory vasoprotective effects of caloric restriction in aging: role of circulating factors and SIRT1.Mechanisms of ageing and development · 2009Article
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Authors and funding
10 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Obesity and reduction in central arterial distensibility, respectively, have been identified as powerful and independent risk factors for cardiovascular disease. However, the effect of weight reduction on central arterial function in obese subjects has not yet been clarified. We investigated whether low-calorie diet-induced weight reduction affects central arterial distensibility and endothelial function in middle-aged obese men. Twelve obese men (age: 45+2 yrs, BMI: 30+1 kg/m 2) completed a 12-week dietary intervention. Caloric restriction induced significantly weight loss and decrease in BMI. After the program, carotid arterial compliance significantly increased and b-stiffness index and aortic pulse-wave velocity remarkably decreased. Concentrations of plasma endothelin-1 (ET-1) significantly decreased and plasma nitric oxide (NO) markedly increased after the program. Weight reduction by low-calorie diet in obese men increases central arterial distensibility, which may contribute to the improvement in endothelial function, as noted by a decrease in ET-1 and an increase in NO.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.