ArticleThe Journal of allergy and clinical immunology2009
Impairing oral tolerance promotes allergy and anaphylaxis: a new murine food allergy model.
Article in The Journal of allergy and clinical immunology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 75 papers.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
75 citing papers in PubMed, 171 citations in OpenAlex.
- Association of Staphylococcus aureus colonization with food allergy occurs independently of eczema severity.The Journal of allergy and clinical immunology · 2019Trial
- Staphylococcal enterotoxin B-derived haptens promote sensitization.Cellular & molecular immunology · 2013Trial
- Involvement of the PD-1 pathway in the modulation of immune responses during allergic diseases.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2026Review
- Mouse Models of Food Allergies: Where Do They Take Us?Clinical reviews in allergy & immunology · 2026Review
- Cpg boosts peptide-based oral immunotherapy in mice with peanut allergy.Frontiers in allergy · 2026Article
- Food allergy: begin at the skin, end at the mast cell?Nature reviews. Immunology · 2025Review
- Genetic background and microbiome drive susceptibility to epicutaneous sensitization and food allergy in adjuvant-free mouse model.Frontiers in immunology · 2024Article
- Akkermansia muciniphila exacerbates food allergy in fibre-deprived mice.Nature microbiology · 2023Article
- Environmental Exposure to Foods as a Risk Factor for Food Allergy.Current allergy and asthma reports · 2023Review
- Enterosorbents in complex therapy of food allergies: a focus on digestive disorders and systemic toxicity in children.Frontiers in immunology · 2023Review
- Preclinical evaluation of alternatives to oral immunotherapy for food allergies.Frontiers in allergy · 2023Review
- Asymptomatic sensitization to a cow's milk protein induces sustained neuroinflammation and behavioral changes with chronic allergen exposure.Frontiers in allergy · 2022Article
- Induction of Hypersensitivity with Purified Beta-Lactoglobulin as a Mouse Model of Cow's Milk Allergy.Methods in molecular biology (Clifton, N.J.) · 2021Article
- Mouse Models of Food Allergy in the Pursuit of Novel Treatment Modalities.Frontiers in allergy · 2021Review
- Induction of Peanut Allergy Through Inhalation of Peanut in Mice.Methods in molecular biology (Clifton, N.J.) · 2021Article
- Epicutaneous sensitization in the development of food allergy: What is the evidence and how can this be prevented?Allergy · 2020Review
- Group 2 Innate Lymphoid Cells Promote Development of T Follicular Helper Cells and Initiate Allergic Sensitization to Peanuts.Journal of immunology (Baltimore, Md. : 1950) · 2020Article
- Review
- Immunological Outcomes of Allergen-Specific Immunotherapy in Food Allergy.Frontiers in immunology · 2020Review
- Antigen-Presenting Cells in Food Tolerance and Allergy.Frontiers in immunology · 2020Review
15 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
backgroundFood allergy is a disorder in which antigenic food proteins elicit immune responses. Animal models of food allergy have several limitations that influence their utility, including failure to recapitulate several key immunologic hallmarks. Consequently, little is known regarding the pathogenesis and mechanisms leading to food allergy. Staphylococcus aureus-derived enterotoxins, a common cause of food contamination, are associated with antigen responses in atopic dermatitis.
objectiveWe hypothesized that S aureus-derived enterotoxins might influence the development of food allergy. We examined the influence of administration of staphylococcal enterotoxin B (SEB) with food allergens on immunologic responses and compared these responses with those elicited by a cholera toxin-driven food allergy model.
methodsOral administration of ovalbumin or whole peanut extract with or without SEB was performed once weekly. After 8 weeks, mice were challenged with oral antigen alone, and the physiologic and immunologic responses to antigen were studied.
resultsSEB administered with antigen resulted in immune responses to the antigen. Responses were highly T(H)2 polarized, and oral challenge with antigen triggered anaphylaxis and local and systemic mast cell degranulation. SEB-driven sensitization induced eosinophilia in the blood and intestinal tissues not observed with cholera toxin sensitization. SEB impaired tolerance specifically by impairing expression of TGF-beta and regulatory T cells, and tolerance was restored with high-dose antigen.
conclusionsWe demonstrate a new model of food allergy to oral antigen in common laboratory strains of mice that recapitulates many features of clinical food allergy that are not seen in other models. We demonstrate that SEB impairs oral tolerance and permits allergic responses.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.